| Issue |
J Extra Corpor Technol
Volume 27, Number 4, December 1995
|
|
|---|---|---|
| Page(s) | 227 - 231 | |
| DOI | https://doi.org/10.1051/ject/1995274227 | |
| Published online | 18 August 2023 | |
Review Article
Lipoprotein(a) and Coronary Heart Disease
1
Department of Cardiovascular Perfusion, Easton Hospital, Easton, Pennsylvania
2
Department of Molecular Biology, Lehigh University, Bethlehem, Pennsylvania
* Address correspondence to: Annette Basile-Borgia, MS, CCP, Department of Cardiovascular Perfusion, Easton Hospital, 250 South 21st Street, Easton, PA 18042
The physiological role of lipoprotein(a) (Lp[a]) has yet to be established, though its structure is well known; it is a low density lipoprotein-like particle with structural homology to plasminogen. It is considered to be linked to atherosclerotic vascular disease, associated with atherothrombotic lesions and an acute phase reactant. The purpose of this paper is to review these three aspects of Lp(a), and to discuss recent observations of Lp(a) in the patient with coronary heart disease. Of particular interest is the application of lipoprotein removal.
Key words: lipoprotein(a) / atherogenesis / thrombogenesis / acute-phase protein / LDL-apheresis
© 1995 AMSECT
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