Abstract

Argatroban in Short-Term Percutaneous Ventricular Assist Subsequent to Heparin-Induced Thrombocytopenia

^* Vanderbilt Heart Institute, Vanderbilt University Medical Center, Nashville, Tennessee
^† Division of Perfusion Services, Vanderbilt University Medical Center, Nashville, Tennessee
^‡ Department of Cardiothoracic Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee

Address correspondence to: David P. Webb, Chief/Program Director, Perfusion, Vanderbilt University Medical Center, 2971 TVC 1211 22nd Avenue SO, Nashville, TN 37232. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Heparin-induced thrombocytopenia paradoxically is a transient pro-thrombotic disorder triggered by heparin exposure. If not treated appropriately, it can be life threatening because of its related thromboembolic complications. In particular, it presents a unique challenge in patients needing extracorporeal life support, because anticoagulation is essential for safe management. This case report describes the safe, efficacious use of Argatroban during short-term support of a patient with a percutaneously inserted left ventricular assist TandemHeart device.