Biomarker response to infection. Legend: Biomarker response to the development of infection (Lines indicate median values; boxes indicate 25–75th percentiles; and whiskers indicate the range). Day-3 represents 72 h in advance of infection (N = 10), day-2 represents 48 h in advance of infection (N = 10), day-1 represents 24 h in advance of infection (N = 10) and day 0 represents the day the culture was obtained that developed an infection (N = 7). Soluble Triggering Receptor expressed on Myeloid cells (sTREM-1), C-Reactive Protein (CRP), Procalcitonin (PCT).