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Table 3
Primary and secondary endpoints. Definition of abbreviations: AKI = acute kidney injury; NGAL = neutrophil gelatinase-associated lipocalin; Cr = creatinine; LCOS = Low cardiac output syndrome; mABP = mean arterial blood pressure; RBC = red blood cell; ICU = intensive care unit. Data represent mean ± SD, number (%), RR[CI].
| Continuous (n = 50) | Non-continuous (n = 50) | Relative risk [95 %CI] or odd ratio [95%CI] | P value | |
|---|---|---|---|---|
| Development of AKI | 8 (16.0) | 6 (12.0) | 0.72 [0.23 to 2.23] | 0.330 |
| AKI stage 1, n (%) | 7 (14.0) | 6 (12.0) | 0.84 [0.26 to 2.69] | 0.766 |
| AKI stage 2, n (%) | 1 (2.0) | 0 | 0.33 [0.013 to 8.21] | 0.496 |
| AKI stage 3, n (%) | 0 | 0 | 1.0 [0.019 to 51.38] | 1.000 |
| Urine NGAL after cardiac surgery (ng/mL) | 71.7 ± 103.8 | 118.0 ± 291.1 | 0.380 | |
| CSA-NGAL score | ||||
| Tubular damage unlikely, n (%) | 31 (62.0) | 29 (58.0) | 0.85 [0.37 to 1.88] | 0.683 |
| Tubular damage possible, n (%) | 12 (24.0) | 14 (28.0) | 1.2 [0.50 to 3.01] | 0.648 |
| Tubular damage, n (%) | 7 (14.0) | 5 (10.0) | 0.68 [0.20 to 2.31] | 0.538 |
| Severe tubular damage, n (%) | 0 | 2 (4.0) | 5.2 [0.24 to 111.2] | 0.495 |
| NGAL increasing rate (%) | 426.5 ± 795.7 | 992.5 ± 2905.8 | 0.437 | |
| Maximum serum Cr increasing rate within 48 h after surgery (%) | 11.0 ± 29.0 | 9.0 ± 20.9 | 0.891 | |
| Urine output after surgery | ||||
| 0–3 h (mL/kg/h) | 10.0 ± 4.4 | 7.4 ± 4.1 | 0.002 | |
| 3–6 h (mL/kg/h) | 3.3 ± 2.2 | 3.0 ± 1.5 | 0.756 | |
| 6–9 h (mL/kg/h) | 1.6 ± 1.1 | 1.5 ± 0.84 | 0.684 | |
| 9–12 h (mL/kg/h) | 1.1 ± 0.92 | 1.2 ± 1.1 | 0.475 | |
| Furosemide dose rate after cardiac surgery, n (%) | 4 (8.0%) | 6 (12.0%) | 0.505 | |
| Nadir mABP (mmHg) | 54.3 ± 8.3 | 53.2 ± 7.5 | 0.761 | |
| Postoperative LCOS, n (%) | 0 | 0 | 1.000 | |
| No. of RBC units (u) | 2.4 ± 2.8 | 2.3 ± 3.1 | 0.582 | |
| PaO2/FiO2 ratio | 325.8 ± 104.5 | 277.1 ± 110.9 | 0.009 | |
| Intubation time (h) | 7.0 ± 5.4 | 9.5 ± 12.4 | 0.271 | |
| Length of ICU stay (d) | 1.0 ± 0.49 | 1.4 ± 1.6 | 0.078 | |
| Length of postoperative hospital stay (d) | 10.2 ± 6.1 | 9.6 ± 3.9 | 0.717 | |
| Hospital mortality, n (%) | 0 | 0 | 1.000 |
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