Table 1
Association of demographic, ECMO, and clinical characteristics with significant cholestasis.
| Characteristic | No significant cholestasis (n = 24) |
Significant cholestasis (n = 6) |
p-value |
|---|---|---|---|
| N (%) | N (%) | ||
| Sex | >0.9 | ||
| Male | 17 (70.83) | 4 (66.67) | |
| Female | 7 (29.17) | 2 (33.33) | |
| Gestational age in weeks, mean (SD) | 37.91 (1.97) | 37.50 (1.68) | 0.6 |
| Birth weight in grams, mean (SD) | 2,905 (590) | 2,936 (371) | 0.8 |
| Primary disease process | 0.2 | ||
| Congenital diaphragmatic hernia | 16 (66.67) | 2 (33.33) | |
| Pulmonary hypoplasia secondary to renal disease | 3 (12.50) | 3 (50.00) | |
| Other | 5 (20.83) | 1 (16.67) | |
| ECMO type | >0.9 | ||
| Venous-arterial | 23 (95.83) | 6 (100.00) | |
| Venous-venous | 1 (4.17) | 0 (0.00) | |
| Oxygenator type | 0.019 | ||
| Pediatric quadrox | 10 (41.67) | 6 (100.00) | |
| Adult quadrox | 14 (58.33) | 0 (0.00) | |
| Pump type | >0.9 | ||
| Affinity | 22 (95.65) | 6 (0.00) | |
| Bio-console | 1 (4.35) | 0 (0.00) | |
| Unknown | 1 (4.35) | 0 (0.00) | |
| Day of life cannulated onto ECMO, mean (SD) | 1.75 (2.77) | 1.17 (2.40) | 0.5 |
| Venous cannula size (Fr) | 0.11 | ||
| 8 | 3 (12.50) | 0 (0.00) | |
| 10 | 7 (29.17) | 4 (66.67) | |
| 12 | 13 (54.17) | 1 (16.67) | |
| 13 | 1 (4.17) | 0 (0.00) | |
| 14 | 0 (0.00) | 1 (16.67) | |
| Arterial cannula size (Fr) | 0.046 | ||
| 6 | 1 (4.35) | 0 (0.00) | |
| 8 | 10 (43.48) | 6 (100.00) | |
| 10 | 12 (52.17) | 0 (0.00) | |
| Days on ECMO, mean (SD) | 14.50 (8.10) | 24.83 (7.11) | 0.017 |
| Percent ACT within goal, mean (SD) | 0.55 (0.24) | 0.70 (0.15) | 0.087 |
| Average RPM, mean (SD) | 1,650.21 (181.11) | 1785.71 (168.42) | 0.093 |
| Average ECMO flow in LPM, mean (SD) | 0.35 (0.06) | 0.34 (0.03) | 0.4 |
| Blood Transfusions in mL/kg | |||
| Packed red blood cells, mean (SD) | 22.85 (18.65) | 36.82 (33.81) | 0.3 |
| Platelets, mean (SD) | 17.26 (14.10) | 17.15 (6.26) | 0.5 |
| Plasma, mean (SD) | 19.49 (20.33) | 17.15 (9.13) | 0.5 |
| Survival to discharge | 11 (45.83) | 3 (50.00) | >0.9 |
P-values for categorical variables are for Fisher’s exact test, p-values for continuous variables are for Wilcoxon rank sum test. Data presented as N (%) for categorical variables unless otherwise stated as Mean (SD). P-values in bold indicate statistical significant, p < 0.05.
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