Open Access
Table 2
Institutional protocol nomogram for low-dose bivalirudin protocol.
| MCS low intensity dosing nomogram |
||||
|---|---|---|---|---|
| aPTT (seconds) | Dosage adjustments |
Repeat aPTT |
||
| Hold infusion | Drip change | CrCl > 30 mL/min | CrCl < 30 mL/min or CRRT/iHD | |
| aPTT < 45 | n/a | Increase infusion rate by 20% | aPTT in 2 h | aPTT in 4 h |
| aPTT 45–60 | n/a | No change (therapeutic) | aPTT in 2 h | aPTT in 4 h |
| aPTT 60.1–85 | Hold infusion for 30 min | Decrease infusion rate by 20% | aPTT in 2 h | aPTT in 4 h |
| aPTT 85.1–100 | Hold infusion for 30 min | Decrease infusion rate by 30% | aPTT in 2 h after resuming | aPTT in 4 h after resuming |
| aPTT 100.1–179.9 | Hold infusion for 60 min | Decrease infusion rate by 40% | STAT aPTT every hour until aPTT < 100, then aPTT in 2 h after resuming | STAT aPTT every hour until aPTT < 100, then aPTT in 4 h after resuming |
| aPTT > 180 | Recheck STAT aPTT as soon as infusion held to make sure the value is not an artifact due to bivalirudin contamination of specimen. After obtaining follow-up aPTT, adjust via nomogram if applicable. If aPTT remains > 180, contact CT Surgery provider to discuss recommendations | |||
CRRT: Continuous renal replacement therapy; iHD: Intermittent hemodialysis.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.