Issue |
J Extra Corpor Technol
Volume 11, Number 5, October 1979
|
|
---|---|---|
Page(s) | 189 - 194 | |
DOI | https://doi.org/10.1051/ject/1979115189 | |
Published online | 11 October 2023 |
Proceedings—Houston 1979
Sodium Nitroprusside As An Adjunct To Pediatric Perfusion
1
The Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550
2
The Department of Anesthesiology, The University of Texas Medical Branch, Galveston, Texas 77550
* Address reprint request to: M. Kurusz, Division of Cardiovascular & Thoracic Surgery, The University of Texas Medical Branch, Galveston, Tx. 77550.
Sodium nitroprusside (N) has been administered to pediatric patients undergoing cardiopulmonary bypass with hypothermia for surgical repair of congenital heart defects. The rationale is to limit peripheral constriction due to cooling while maintaining a high flow perfusion (3.0 to 3.5 L/min/m2). Patients ranging in size from 4.0 to 33.6 kg ( 18.2 mean) and in age from 0.25 to 15 years ( 6.9 mean) have been treated during the past year. While the patients were being cooled to 23°C on pump, N (50 mg/500 cc) was administered into the arterial reservoir of the oxygenator with a minidrip set connected to an infusion pump. Rate of infusion was 2.5 to 10.8 μgm/kg/min (5.4 , μgm/kg/mean). The mean arterial pressure was maintained at 40 to 50 mmHg. Once the patients were at 23°C, N infusion was discontinued. Hypothermic potassium arrest of the heart was used in conjunction with this technique following aortic cross-clamping. N was administered again during rewarming at a slightly higher rate of infusion than when cooling. Advantages of the technique are increased tissue perfusion as evidenced by increased urine output on bypass, decreased fluid replacement in the postoperative period, and uniform body cooling/rewarming.
© 1979 AMSECT
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.