Issue |
J Extra Corpor Technol
Volume 17, Number 2, June 1985
|
|
---|---|---|
Page(s) | 65 - 73 | |
DOI | https://doi.org/10.1051/ject/1985172065 | |
Published online | 13 September 2023 |
Original Article
Metabolic Rate, Temperature, and Acid-Base Control: The Best Strategy and Our Needs to Achieve It
Research Institute for Biological Science, Lakewood, CO
* Direct communications to Henry Swan, M.D., D.Sc (Hon.) FACS, Research Institute for Biological Science, 6700 W. Lakeridge Rd., Lakewood, CO 80227.
Important recent knowledge concerning acid-base status during hypothermia is briefly summarized. A basic diagram of pH-CO2 relationships during cooling with diluted blood is presented to illustrate the three possible acid-base management strategies during hypothermic perfusion. On the basis of an extensive review of pertinent literature on the effect of excess CO2 and acidosis on the hypothermic brain and heart during hypothermic cardiopulmonary bypass (H-CPB), it is recommended that no CO2 be added to any ventilatory gas and that respiratory alkalosis is the optimal acidbase strategy during perfusion cooling with circulatory arrest. The great need for on-line blood gas monitoring instrumentation, so that perfusionists may actually identify and control the acid-base status of the patient during hypothermia, is emphasized.
© 1985 AMSECT
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