Issue |
J Extra Corpor Technol
Volume 18, Number 2, June 1986
|
|
---|---|---|
Page(s) | 34 - 40 | |
DOI | https://doi.org/10.1051/ject/1986182034 | |
Published online | 12 September 2023 |
Original Article
Efficacy of Apneic Oxygenation with Extracorporeal Carbon Dioxide Removal for Ventilatory Support during Acute Respiratory Failure
Division of Circulation Technology, School of Allied Medical Professions, The Ohio State University, Columbus, OH
* Direct communications to: Philip D. Beckley, M.S., Circulation Technology, 1583 Perry Street, Columbus, OH 43210
Apneic oxygenation (AO) with extracorporeal carbon dioxide removal (ECCO2R) was investigated as a gas exchange support technique during acute respiratory failure (ARF). The purpose of this work was to study the limitations of AO and ECCO2R in the pig challenged with pulmonary artery infusions of E. Coli endotoxin as a model of ARF. Fourteen animals of 36.5 kg average weight were placed on AO with simultaneous ECCO2R accomplished with a venovenous bypass through a membrane lung. Bypass blood flow rate remained constant at 1 L/min in all trials. Inlet gas fraction (FiO2) was varied between 0.209 and 1.0. With ECCO2R, arterial pCO2 and pH were held to mean values of 36.9 mmHg and 7.41 respectively. Arterial pO2 was directly related to the membrane lung FiO2 and was inversely related to pulmonary shunt resulting from the ARF. AO with ECCO2R was shown to be an easily manageable ventilatory support technique capable of meeting the gas exchange requirements of a porcine model of endotoxin induced respiratory distress.
© 1986 AMSECT
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.