Issue |
J Extra Corpor Technol
Volume 19, Number 3, September 1987
|
|
---|---|---|
Page(s) | 290 - 296 | |
DOI | https://doi.org/10.1051/ject/1987193290 | |
Published online | 29 August 2023 |
Original Article
The Effect of Hemodilution on Cold Agglutinins
1
The Ohio State University, Columbus, OH
2
Mobile Infirmary Medical Center, Mobile, AL
* Direct communications to: Kimberly S. Gallimore, SETA, Inc., 181 Louiselle St., Mobile, AL 36607
(J. Extra-Corpor. Technol. 19[3] p. 290-296 Fall 1987, 14 ref.) The effect of hypothermia in patients with cold agglutinin disease was studied in a patient with a strongly positive agglutination at 4°C (1:16,000 titer, a thermal amplitude of 30°C or less, and a specific I antibody). The study investigates a method of hemodilution by which patients with cold agglutinin disease may safely undergo hypothermia during cardiopulmonary bypass. By diluting the blood with an isotonic solution, the tendency toward agglutination of red blood cells is reduced, along with the risks associated with hypothermia in the patient with cold agglutinin disease.
It was concluded that as the degree of hemodilution of the blood is increased, hemodilution reduced the tendency toward aggregation of red blood cells during hypothermia when cold agglutinins are present in the blood. As a result, hemodilution may enable a patient with cold agglutinin disease to safely undergo cold cardioplegia and cardiac arrest during hypothermic conditions.
Key words: agglutinin / cold / cardioplegia / hypothermic / complication / hypothermia / hemodilution / hypothermia / complication
© 1987 AMSECT
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