Original Article

Hematological Effects during Clinical Extracorporeal Circulation: A 200 Case Study of the Shiley M-2000 Membrane System

Department of Cardiac Surgery, AMI Alexandria Hospital, Cheshire, England

^* Direct communications to: J. E. Briddon, Department of Cardiac Surgery, AMI Alexandria Hospital, Mill Lane, Cheadle, Cheshire, England SK8 2PZ

Abstract

(J. Extra-Corpor. Technol. 19[3] p. 312-315 Fall 1987, 6 ref.) The hematological effects of the Shiley M-2000 Membrane Oxygenator System were evaluated during and after cardiopulmonary bypass (CPB) in 200 patients who required coronary artery revascularization. A strict protocol for perfusion management and blood sampling was established and adhered to. Bypass times varied from 11/2 hours to 81\2 hours (X = 2 hrs 48 mins). Hemolysis was observed to be minimal, blood cells were well preserved, and, in particular, platelet counts and platelet function remained stable, even in bypass times in excess of 8 hours.

It was noted that when CPB was discontinued, and protamine sulphate infusion commenced, platelet function decreased slightly, although the platelet counts remained unchanged. Average postoperative blood loss was 390 mls (21 0 mls-1 ,400 mls range), statistically significantly lower than the average blood loss in a previous study at our center, which utilized the same protocol but an alternative membrane (Cobe CML).

In summary the Shiley M-2000 Membrane is a safe and extremely hemocompatible system for use in short- to medium-term perfusions.