Issue |
J Extra Corpor Technol
Volume 20, 1988
Proceedings of AmSECT’s 26th International Conference
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Page(s) | 7 - 10 | |
DOI | https://doi.org/10.1051/ject/198820S007 | |
Published online | 25 August 2023 |
Original Article
Comparison of Venous Oxygen Partial Pressure (PvO2) and Oxygen Saturation (SvO2) in Hypothermic Blood Flow Control
Extra-Corporeal Circulation Technology, Medical University of South Carolina, Charleston, SC
* Direct communications to: Robin G. Sutton, Extra-corporeal Circulation Technology, College of Health Related Professions, Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29425.
Mixed venous oxygen content is commonly used to determine the adequacy of oxygenation during cardiopulmonary bypass (CPB). Due to the shift in the oxyhemoglobin disassociation curve during hypothermia, it is unknown whether PvO2 or SvO2 is the best indicator of adequate perfusion. The purpose of this study was to determine if there were any differences in blood flow, calculated base deficit, total fluids, hematocrit and oxygen consumption for dogs in the following two groups: PvO2 between 35–45mmHg and SvO2 between 65–75%. Blood flow was managed in fourteen animals randomly assigned to the PvO2 and SvO2 group during hypothermic CPB. PvO2 management required significantly higher blood flows and total fluids (p<0.05). Hematocrit was significantly higher in the SvO2 group (p<0.05). No differences were detected between the two techniques in base deficit or oxygen consumption (p>0.4). These results suggest that in the canine model SvO2 monitoring during hypothermic CBP is a better indicator of tissue perfusion because of lower blood flows, fluid requirement, and higher hematocrits.
© 1988 AMSECT
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