Issue |
J Extra Corpor Technol
Volume 23, Number 3, September 1991
|
|
---|---|---|
Page(s) | 80 - 85 | |
DOI | https://doi.org/10.1051/ject/199123380 | |
Published online | 21 August 2023 |
Original Article
Coagulation Patterns in Perfusion with Low Systemic Heparinization
Clinic for Cardiovascular Surgery, Institute of Anesthesiology, and Department of Medicine, University Hospital, Zurich, Switzerland
* Address correspondence to: Ludwig K. von Segesser, MD, Clinic for Cardiovascular Surgery, University Hospital, CH-8091 Zurich, Switzerland. Phone: 41 1 255 11 11 extension 142 332 Fax: 41 1 255 44 46
Cardiopulmonary bypass (CPB) with heparin coated perfusion equipment was realized in 13 patients undergoing myocardial revascularization with either low (ACT> 180) or full systemic heparinization (ACT>480). Blood samples for coagulation and other studies were drawn before, after heparin, and at regular intervals during and after CPB.
Heparinization | low | full | p< | |
Preop | ACT s | 118±6 | 112±13 | NS |
PTT s | 38±4 | 35±2 | NS | |
TT s | 14±1 | 14±1 | NS | |
D-dimers mg/L | <05 | <0.5 | NS | |
Heparin | IU 103 | 8±2 | 51±9 | .01 |
CPB 60 min | ACT s | 230±19 | 594±287 | .05 |
PTT s | 56±9 | 94±63 | .10 | |
TT s | >200 | >200 | NS | |
D-dimers mg/L | <0.5 | <0.5 | NS | |
Protamin | IU 103 | 7±1 | 30±4 | .01 |
60 min | ACT s | 110±11 | 109±9 | NS |
PTT s | 47±6 | 48±10 | NS | |
TT s | 19±6 | 19±8 | NS | |
D-dimers mg/L | 0.6±0.5 | 1.1±0.6 | NS | |
Blood loss day 1 L/m2 | 0.4±0.1 | 1.0±1.0 | .05 |
We conclude, that low dose systemic heparinization (16% of full) resulted in adequate anticoagulation during perfusion with heparin coated equipment and in reduced blood loss.
Key words: Cardiopulmonary bypass / coagulation / heparin / coronary artery bypass
© 1991 AMSECT
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