Issue |
J Extra Corpor Technol
Volume 24, Number 4, December 1992
|
|
---|---|---|
Page(s) | 116 - 119 | |
DOI | https://doi.org/10.1051/ject/1992244116 | |
Published online | 21 August 2023 |
Original Article
Laboratory Evaluation of a Low Prime ClosedCircuit Cardiopulmonary Bypass System
Columbia-Presbyterian Medical Center, New York
* Address correspondence to: Joseph J. Sisti no Columbia-Presbyterian Medical Center, N.Y. MHB 4-350 New York, N.Y. 10032
We have explored the potential advantages of a low prime closed-circuit cardiopulmonary bypass (CPB) system using a non-human primate model. Although manufacturers have reduced priming volumes in individual CPB components, the standard circuit volume remains high because of the tubing diameter and length necessary for gravity drainage. By replacing gravity drainage with the negative pressure generated by a centrifugal pump, we can realize significant tubing volume reduction.
Closed-circuit bypass was conducted on 13 baboons ranging from 5-15 kg. The circuit consisted of a centrifugal pump, a hollow fiber oxygenator, and l/4" arterial and venous tubing. The design of the circuit included the capacity to remove a limited amount of venous air. Circulatory arrest during deep hypothermia with volume displacement into a reservoir was also accomplished with this circuit.
The potential benefits of this low prime closed-circuit bypass system include blood conservation and reduction in blood surface area contact. The future safe clinical use of this type of closed-circuit bypass for routine open heart surgery will depend upon the incorporation of a device in the venous line to remove air. This is the greatest threat to patient safety in a closed circuit system and its use for open chest surgery must wait until an efficient venous air elimination device is available.
Key words: Prime / extracorporeal circuit / volume management / centrifugal blood pump / pre-clinical
© 1992 AMSECT
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