Issue |
J Extra Corpor Technol
Volume 25, Number 3, September 1993
|
|
---|---|---|
Page(s) | 87 - 92 | |
DOI | https://doi.org/10.1051/ject/199325387 | |
Published online | 21 August 2023 |
Original Article
The Relationship Between Membrane Oxygenator Blood Path Pressure Drop and Hemolysis: An In-vitro Evaluation
Sarns, 3M Health Care, Ann Arbor, Michigan
* Address correspondence to: Mark Bearss, CCP, 6200 Jackson Road, Ann Arbor, MI 48103
Plasma hemoglobin (pl-Hgb) production was measured for the Bard HF-5000 (n = 4), Sarns SMO (n =4) and Sarns Turbo (n =4) membrane oxygenators (MO), which were tested on separate closed-loop roller pump circuits to compare differences in hemolysis production as a function of pressure drop (P). The three oxygenators were selected because of their varied P characteristics. Circuits were prepared by clamping off the MO and then priming with freshly drawn, heparinized, filtered bovine blood that had an adjusted hemoglobin (Hgb) of 8.0 g/dL. Roller pump occlusions were set using a pressure transducer. To correct for hemolysis resulting from the roller pump in each oxygenator circuit, the blood was pumped through a bypass line around each MO for the first 90 minutes of each study. Blood flows were maintained at 4.0 L/min at a pressure of 200 mmHg and tests for pl-Hgb conducted at 30-minute intervals. Blood was then circulated through each MO for 180 minutes at outlet pressures of 200 mmHg. Total pl-Hgb values were corrected for flow and time in order to calculate a hemolysis index (HI) in grams of pl-Hgb generated per 100 L of blood pumped.
A weak correlation was demonstrated between P and HI (r = 0.69). This study suggests that variances in MO hemolysis are a function of design variables, such as membrane surface area, prime volume, and blood path length, rather than of P. The pl-Hgb generated from each MO was negligible when compared with typical pl-Hgb levels generated during routine cardiopulmonary bypass.
Key words: cardiopulmonary bypass / membrane oxygenators / hemolysis index / plasma hemoglobin / pressure drop
© 1993 AMSECT
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.