Original Article

Application of Polygeline in Pediatric Cardiac Surgery

Department of Pediatric Cardiothoracic Surgery, Xin-Hua Hospital, Shanghai Second Medical University

^* Address correspondence to: De-Ming Zhu, MD, Pediatric Cardiovascular Surgery, Xin Hua Hospital, Shanghai Second Medical Univ., 1665 Kong Jiang Road, Shanghai 200092 China

Abstract

The purpose of this study was to determine the effect of using polygeline as part of the cardiopulmonary bypass solution in pediatric cardiac surgery.

A total of 40 cases were divided into two groups, a polygeline group (H group, n=20) and a plasma group (P group, n=20). Operations were performed under routine extracorporeal circulation. The dose of polygeline or plasma used was calculated to maintain the patient's plasma colloid oncotic pressure at 10-12 mmHg.

The results showed that in the polygeline group, no patient developed allergic or coagulation disorders even after large volumes of polygeline were used (45 ml/kg). At the initiation and completion of cardiopulmonary bypass (CPB), the concentrations of calcium were higher in the H group (1.38 ± 0.19, 1.21 ± 0.11) than those (0.72 ± 0.11, 0.95 ± 0.10) in the P group. There were no other statistically significant differences between the two groups. There were no organ problems in the patients included in the study.

This study demonstrated that polygeline could be used as part of prime solution instead of plasma to keep an ideal plasma colloid oncotic pressure, reduce infections caused by blood product transfusions and lower the cost to the patients.