Issue |
J Extra Corpor Technol
Volume 33, Number 2, June 2001
|
|
---|---|---|
Page(s) | 117 - 125 | |
DOI | https://doi.org/10.1051/ject/2001332117 | |
Published online | 14 August 2023 |
Original Article
Use of Ecarin Clotting Time (ECT) with Lepirudin Therapy in Heparin-Induced Thrombocytopenia and Cardiopulmonary Bypass
UPMC Presbyterian Perfusion Services Department, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
* Address correspondence to: M. Charlene Fabrizio, RN, CCP, Perfusion Services Department, Room F 1051.1, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213. E-mail: fabriziomc@msx.upmc.ed
Received:
10
June
2000
Accepted:
30
November
2000
Heparin-induced thrombocytopenia (HIT) is described as an allergy-like adverse reaction to heparin. It is a potentially severe complication of heparin therapy that can result in serious or life–threatening venous or arterial thromboembolic events. In the United States, lepirudin (Aventis Pharma AG, Strasbourg, France) is an approved therapy for anticoagulation in patients with HIT requiring anticoagulation. Lepirudin is a recombinant form of hirudin, a leech enzyme that is a highly specific direct inhibitor of thrombin. Lepirudin monitoring during surgery can be managed with ecarin clotting time (ECT) (Cardiovascular Diagnostics, Inc., Raleigh, NC), which has recently been approved as a humanitarian device exemption (HDE) for use in the United States in the management of HIT with cardiopulmonary bypass. This case report describes a patient with HIT who was managed successfully with lepirudin and ECT during coronary artery bypass grafting.
Key words: ecarin clotting time / heparin-induced thrombocytopenia / hirudin / lepirudin / cardiopulmonary bypass / thrombolastograph
© 2001 AMSECT
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.