Issue |
J Extra Corpor Technol
Volume 33, Number 4, December 2001
|
|
---|---|---|
Page(s) | 223 - 226 | |
DOI | https://doi.org/10.1051/ject/2001334223 | |
Published online | 14 August 2023 |
Balanced Ultrafiltration, Modified Ultrafiltration, and Balanced Ultrafiltration with Modified Ultrafiltration in Pediatric Cardiopulmonary Bypass
Department of Pediatric Thoracic and Cardiovascular Surgery, Shanghai Children’s Medical Center, Shanghai Second Medical University, Shanghai, People’s Republic of China 200127
* Address correspondence to: Zhu De Ming, MD, Department of Pediatric Thoracic and Cardiovascular Surgery, Shanghai Children’s Medical Center, 1678 Dong Fang Road, Shanghai Second Medical University, Shanghai, People's Republic of China, e-mail: weiwangww@etang.com
Received:
25
March
2001
Accepted:
11
October
2001
This study evaluates the effect of balanced ultrafiltration, modified ultrafiltration, and balanced ultrafiltration with modified ultrafiltration on inflammatory mediators in children’s open-heart surgery. Eighty children with congenital heart disease were randomly divided into four groups: control group (C group); balanced ultrafiltration group (BUF group); modified ultrafiltration group (MUF group); and balanced ultrafiltration with modified ultrafiltration group (B+M group). Clinical data of these groups were similar. Tumor necrosis factor (TNF), interleukin-8(IL-8), and E-selectin were measured at the beginning of cardiopulmonary bypass (CPB), 30 min later, at the cessation of CPB, at the cessation of MUF (MUF group and B+M group), and 2 hours postoperatively. During CPB, the concentrations of TNF, IL-8, and E-selectin increased significantly in C and MUF groups and did not change significantly in BUF and B+M groups. In the period of MUF, TNF and IL-8 increased; whereas, Eselectin did not change. The study shows that ultrafiltration can filter out the inflammatory mediators, but only BUF can decrease the concentrations of them. Moreover, MUF only can concentrate blood. Combining both techniques has both effects, but the effect of BUF was offset by MUF.
Key words: ultrafiltration / cardiopulmonary bypass / inflammatory mediator
© 2001 AMSECT
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