Issue |
J Extra Corpor Technol
Volume 36, Number 2, June 2004
|
|
---|---|---|
Page(s) | 197 - 201 | |
DOI | https://doi.org/10.1051/ject/2004362197 | |
Published online | 08 August 2023 |
Relationship of Aging and Cardiac IL-10
The Circulatory Science Graduate Perfusion Program, Department of Surgery, College of Medicine, The University of Arizona, Tucson, Arizona
* Address correspondence to: Douglas F. Larson, PhD, Department of Surgery, Room 4402, College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724. E-mail: dflarson@u.arizona.edu
Current therapies for the treatment of myocardial infarction and heart failure include medical, surgical, mechanical assist, and transplantation. These therapies have been based on the dogma that ventricular myocytes themselves are terminally differentiated and, therefore, cannot regenerate. This concept has been recently challenged with stem cell therapy. A potential problem is the ability of cardiac tissue to mobilize, recruit, and transdifferentiate adult stem cells from other tissues. We believe that there is a unique failure of the damaged myocardium to provide the appropriate molecular signals for stem cells engraftment related to age. Our hypothesis is that the overexpression of IL-10 in the aged population reduces cardiac cellular proliferation subsequent to myocardial injury. This hypothesis is supported by aging models, where elevated levels of IL-10 are associated with reduced healing response to noncardiac tissue injury. We demonstrated an increased cardiac gene expression of IL-10 that may be associated with a reduced proliferative response in the border regions of the infarcted myocardium that are proportional with age. In conclusion, myocardial infarction and heart failure has presented a significant challenge for the clinician to provide reparative therapies. The use of therapeutics to modulate IL-10 and, thereby, optimizing regenerative processes in the injured myocardium may provide a unique means for the cardiac patient.
Key words: aging / myocardial regeneration / IL-10 / stem cells
© 2004 AMSECT
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