| Issue |
J Extra Corpor Technol
Volume 38, Number 2, June 2006
|
|
|---|---|---|
| Page(s) | 168 - 173 | |
| DOI | https://doi.org/10.1051/ject/200638168 | |
| Published online | 15 June 2006 | |
Reviews
Hyperglycemia as an Effect of Cardiopulmonary Bypass: Intra-operative Glucose Management
Address corresponding to: Douglas F. Larson, PhD, Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ 85724. E-mail: dflarson@u.arizona.edu
Cardiopulmonary bypass (CPB) is associated with surgical stress, hypothermia, hyperoxia, enhancement of neuroendocrine outflow, and administration of glucogenic catecholamines that are associated with glucogonolysis and glucogenesis that result in hyperglycemia. The hyperglycemic state during CPB has been associated with adverse outcomes, such as infection, neurological impairment, cardiac dysfunction, prolonged hospitalization, and higher mortality rates. This report justifies vigilant monitoring of blood glucose levels and a rational protocol for the treatment of hyperglycemia of all open heart surgical patients that may improve post-CPB surgical outcomes.
Key words: glucose / glycogen / GLUT2 / GLUT4 / hyperoxia / hypothermia / insulin / hyperglycemia
© 2006 AMSECT
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