Issue |
J Extra Corpor Technol
Volume 45, Number 2, June 2013
|
|
---|---|---|
Page(s) | 94 - 106 | |
DOI | https://doi.org/10.1051/ject/201345094 | |
Published online | 15 June 2013 |
Original Articles
The Effects of Pressure on Gases in Solution: Possible Insights to Improve Microbubble Filtration for Extracorporeal Circulation
Address correspondence to: Daniel P. Herbst, MSc, CCP, CPC, Department of Cardiac Sciences, Mail Code 1413, King Fahad National Guard Hospital, P.O. Box 22490, Riyadh, Kingdom of Saudi Arabia. E-mail: d_hebrst@me.com
Received:
13
January
2013
Accepted:
8
May
2013
Improvements in micropore arterial line filter designs used for extracorporeal circulation are still needed because microbubbles larger than the rated pore sizes are being detected beyond the filter outlet. Linked to principles governing the function of micropore filters, fluid pressures contained in extracorporeal circuits also influence the behavior of gas bubbles and the extent to which they are carried in a fluid flow. To better understand the relationship between pressure and microbubble behavior, two ex vivo test circuits with and without inline resistance were designed to assess changes in microbubble load with changes in pressure. Ultrasound Doppler probes were used to measure and compare the quality and quantity of microbubbles generated in each test circuit. Analysis of microbubble load was separated into two distinct phases, the time periods during and immediately after bubble generation. Although microbubble number decreased similarly in both test circuits, changes in microbubble volume were significant only in the test circuit with inline resistance. The test circuit with inline resistance also showed a decrease in the rate of volume transferred across each ultrasound Doppler probe and the microbubble number and size range measured in the postbubble generation period. The present research proposes that fluid pressures contained in extracorporeal circuits may be used to affect gases in solution as a possible method to improve microbubble filtration during extracorporeal circulation.
Key words: microbubble / arterial line filter / filtration / CPB equipment / patient safety
© 2013 AMSECT
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