J Extra Corpor Technol
Volume 51, Number 3, September 2019
|147 - 152
|15 September 2019
Perfusion Methods and Modifications to the Cardiopulmonary Bypass Circuit for Midline Unifocalization Procedures
Address correspondence to: Richard D. Mainwaring, MD, Stanford University School of Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA 94305. E-mail: email@example.com
Accepted: 2 August 2019
Pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries (PA/VSD/MAPCAs) is a rare form of congenital heart disease. The midline unifocalization procedure has been developed for the treatment of PA/VSD/MAPCAs. These are complex and very lengthy procedures that require an entirely different method of perfusion. The purpose of this study was to review our perfusion modifications to support these unifocalization procedures. Sixty-four unifocalization procedures have been performed at our institution during the past 3 years. The median age was 4.1 months (range 1 month–3.5 years) and the median weight at surgery was 4.5 kg (range 3.5–19 kg). The median duration of cardiopulmonary bypass was 352 minutes (range 128–629 minutes), and the median duration of cross-clamp was 24 minutes (range 14–72 minutes). The conduct of surgery included cooling to a rectal perfusion temperature of 25° and a flow rate of 100 mL/kg/min. A pH-stat strategy and del Nido cardioplegia were used. Modifications to the cardiopulmonary bypass circuit include upsizing the oxygenator, reservoir, cannulae, vent catheter, and tubing. All circuits were modified to include the capability of performing an intraoperative flow study. This study is used to determine whether the VSD can be closed during surgery. A collateral flow study circuit is also set up for first-time operations to measure the residual collateral flow after all of the MAPCAs have been harvested. Patients who require midline unifocalization will invariably require very lengthy periods of support on cardiopulmonary bypass. We have adapted our perfusion circuitry to prepare for the demands on the bypass circuit to meet the requirements of this patient population. Our institution has developed a systematic approach for the conduct of perfusion to best serve our patients presenting with PA/VSD/MAPCAs.
Key words: congenital heart disease / pulmonary arteries / veins / pulmonary valve
Presented at the AmSECT Pediatric Conference, Miami, Florida, October 4–6, 2018, winner of the best paper presented at the 2018 AmSECT Meeting.
© 2019 AMSECT
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