Issue |
J Extra Corpor Technol
Volume 53, Number 3, September 2021
|
|
---|---|---|
Page(s) | 214 - 219 | |
DOI | https://doi.org/10.1051/ject/202153214 | |
Published online | 15 September 2021 |
Technique Articles
In Vitro and In Vivo Comparison of Hemoglobin and Electrolytes Following the Collection of Cell Saver Blood Washed with Either Normal Saline or Plasma-Lyte A
Department of Pediatrics, Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, and Department of Congenital Cardiac Surgery, University of Rochester, Rochester, New York
Address correspondence to: Jill M. Cholette, MD, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Avenue, Box # 667, Rochester, NY 14642. E-mail: jill_cholette@rochester.edu
Received:
9
March
2021
Accepted:
7
June
2021
Cell saver blood is typically washed with normal saline (NS); however, recent studies have reported decreased red blood cell hemolysis and increased platelet function when a more physiologic washing solution, such as Plasma-Lyte A (PL-A) is used. We evaluated the in vitro and in vivo effects of NS compared to PL-A as washing solutions for cell saver blood in pediatric cardiac surgery. Cell saver blood was re-infused for up to 24 hours post-collection. Laboratory and clinical data were collected from infants receiving cell saver washed with either NS (n = 20) or PL-A (n = 21). Compositions of the cell saver blood were compared between groups at 5 in vitro time points and in vivo patient blood at 24 hours post-bypass. Although there were differences in in vitro laboratory values between groups; 24 hours post-bypass, in vivo results were similar. Our data supports 24-hour reinfusion of cell saver washed with either NS versus PL-A in pediatric cardiac surgery patients, and provides data on the differences in cell saver composition to guide future studies.
Key words: hemolysis / cell saver / cardiopulmonary bypass / hemoglobin / renal function
© 2021 AMSECT
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