Case Report

Successful use of pulsatile flow and goal directed perfusion in a high-risk patient

¹ Extracorporeal life support, Baqiyatallah University of Medical Sciences, Sheikh Bahayi St. Mollasadra St. Vanak Square, Tehran, Iran
² Midwestern University, 19555 N. 59th Avenue, Glendale, Arizona 85308, USA

^* Corresponding author: hdarban@yahoo.com

Received: 21 September 2024
Accepted: 14 January 2025

Abstract

The development of multi-organ failure resulting from cardiopulmonary bypass (CPB) is acknowledged as a significant contributor to increased morbidity and mortality rates during the postoperative period. This report discusses a patient who presents with multiple comorbidities, including renal failure, reduced ejection fraction, and a history of hypertension, and is being considered for coronary artery bypass grafting (CABG) along with aortic valve replacement surgery. The administration of CPB was customized to address the unique comorbid conditions of the patient, highlighting the critical objective of maintaining an oxygen delivery index (DO₂i) exceeding 280 mL/min/m², while also integrating pulsatile flow methodologies. The management of CPB, as previously discussed, resulted in a notable enhancement of kidney function, accompanied by a reduction in the patient’s lactate levels post-surgery.