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Table 2

Heparin rate adjustments for maintenance infusion protocol.

Start infusion at 15 units/kg/h (max 1800 units/h)
Goal aPTT (44–66, 67–92):
44–66 67–92 Bolus dose Change current infusion Order next PTT
<23 <47 Give maintenance bolus dose Increase rate by 4 units/kg/h 4 h
23–43 47–66 None Increase rate by 2 units/kg/h 4 h
44–66 67–92 None Goal range, continue current rate 4 h × 1, then every AM
67–92 93–107 None HOLD for 30 min, then decrease rate by 2 units/kg/h 4 h
93–107 108–126 None HOLD for 1 h, then decrease rate by 3 units/kg/h 4 h after start of infusion
>107 >126 None HOLD for 2 h, then decrease rate by 4 units/kg/h 4 h after start of infusion

**If PTT > 120 for two consecutive PTT values and/or > 200 for any PTT result, HOLD infusion and notify Physician**.

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