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Table 3
Baseline characteristics of patients (mean 95% or median IQR).
| Characteristics | UFH (n = 10) | Bivalirudin (n = 12) | p-values |
|---|---|---|---|
| Age mean (y) | 49.6 (42–57) | 43.7 (38–49) | 0.16 |
| Weight (kg) | 100 (81–119) | 93.9 (86–102) | 0.5 |
| RACE, No. (%) n = 20 | |||
| White or Caucasian | 0 (0) | 4 (36) | 0.03 Hispanic vs. white |
| Hispanic | 9 (100) | 6 (55) | 0.6 |
| African American | 0 (0) | 1 (8) | 0.6 |
| % Male | 8 (80) | 8 (67) | 0.6 |
| BMI mean (kg/m2) | 34.3 (28–41) | 31.7 (28–35) | NS |
| INR median (s) | 1.3 (1.2–1.5) | 1.3 (1.1–1.4) | 0.6 |
| aPTT baseline mean (s) | 36.5 (33.2–39.7) | 38.6 (31.2–46) | 0.6 |
| Hemoglobin median (g/dL) | 11.3 (9.8–12.7) | 10.2 (8.4–13.1) | 0.14 |
| Hematocrit median (%) | 35.6 (31.6–39.6) | 32.4 (26.8–38) | 0.12 |
| Platelet count median (×103/μL) | 281 (209–423) | 184 (107–265) | 0.052 |
| AST median (IU/L) | 29.5 (23–55) | 26 (18–43) | NS |
| ALT median (IU/L) | 76 (35.5–106) | 30 (22–51) | 0.09 |
| SCr median (mg/dL) | 0.84 (0.6–1.2) | 0.54 (0.4–0.66) | 0.04 |
| Resp. rate (breaths/min) | 28 (20–30) | 30 (24–33) | NS |
| CRRT, No. (%) | 6 (60) | 1 (8) | 0.02 |
| Systolic BP mean (mmHg) | 127 (115–139) | 127 (110–144) | 0.98 |
| Diastolic BP mean (mmHg) | 75 (65–85) | 68 (58–79) | 0.3 |
| HR median (bpm) | 95 (79–111) | 90 (76–104) | 0.6 |
| Oxygen saturation median (%) | 93 (84–97) | 94.5 (87–97) | 0.4 |
| D-Dimer median (mcg/mL) | 2.95 (1.7, 6.2) | 2.35 (2.1–3.3) | 0.3 |
| Apache2 mean | 14.5 (9.7–19.3) | 10.4 (7.8–1.3) | 0.12 |
BMI, body mass index; INR, international normalized ratio; aPTT, activated partial thromboplastin time; SCr, serum creatinine; CRRT, continuous renal replacement therapy; BP, blood pressure; HR, heart rate; NS, non-significant.
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