Open Access
Table 2
Dosing cohort demographics. CPB = cardiopulmonary bypass, AOX = aortic cross clamp.
| A (n = 1779) | B (n = 2129) | C (n = 1613) | p-value | |
|---|---|---|---|---|
| TXA (mg/kg) | ||||
| Cam −ve | 19.4 (19.2 – 19.6) | 24.4 (24.4 – 24.7) | 29.9 (29.9 – 30.3) | |
| Cam +ve | 19.4 (18.2 – 19.8) | 24.7 (24.4 – 25.0) | 30.3 (29.9 – 30.8) | |
| Age (years) | ||||
| Cam −ve | 67 (67.0 – 68.0) | 71 (71.0 – 72.0) | 72 (71.0 – 73.0) | <0.001 |
| Cam +ve | 70 (69.0 – 71.0) | 73 (73.0 – 74.9) | 76 (74.0 – 77.0) | <0.001 |
| Sex | ||||
| Male | ||||
| Cam −ve | 1203 (67%) | 1448 (68%) | 670 (41%) | 0.02 |
| Cam +ve | 242 (14%) | 291 (14%) | 161 (10%) | 0.65 |
| Female | ||||
| Cam −ve | 260 (15%) | 311 (15%) | 629 (39%) | 0.002 |
| Cam +ve | 75 (4%) | 80 (3%) | 153 (10%) | 0.07 |
| Left ventricular function | ||||
| Good | 989 (55%) | 1218 (58%) | 892 (55%) | 0.95 |
| Cam −ve | 171 (10%) | 235 (11%) | 186 (11%) | 0.96 |
| Cam +ve | ||||
| Moderate | ||||
| Cam −ve | 406 (23%) | 466 (22%) | 327 (20%) | 0.88 |
| Cam +ve | 108 (6%) | 104 (5%) | 106 (7%) | 0.85 |
| Severe | ||||
| Cam −ve | 46(2.5%) | 52 (2.5%) | 57 (4%) | 0.90 |
| Cam +ve | 26 (1.5%) | 22 (1%) | 14 (1%) | 0.78 |
| Very severe | ||||
| Cam −ve | 21 (1.2%) | 22 (1%) | 23 (1.5%) | 0.77 |
| Cam +ve | 12 (0.8%) | 10 (0.5%) | 8 (0.5%) | 0.98 |
| Hypertension | ||||
| Yes | ||||
| Cam −ve | 823 (46%) | 963 (45%) | 638 (40%) | 0.79 |
| Cam +ve | 195 (11%) | 209 (10%) | 171 (11%) | 0.97 |
| No | ||||
| Cam −ve | 639 (36%) | 795 (37%) | 661 (40%) | 0.89 |
| Cam +ve | 122 (7%) | 162 (8%) | 143 (9%) | 0.88 |
| Diabetes mellitus | ||||
| Yes | ||||
| Cam −ve | 430 (24%) | 382 (18%) | 208 (13%) | 0.19 |
| Cam +ve | 109 (6%) | 105 (5%) | 61 (4%) | 0.82 |
| No | ||||
| Cam −ve | 1049 (59%) | 1376 (65%) | 1091 (67%) | 0.76 |
| Cam +ve | 208 (11%) | 266 (12%) | 253 (16%) | 0.58 |
| Previous stroke | ||||
| Yes | ||||
| Cam −ve | 79 (4%) | 103 (4%) | 65 (4%) | 0.98 |
| Cam +ve | 23(1%) | 36 (2%) | 25 (1%) | 0.78 |
| No | ||||
| Cam −ve | 1383 (78%) | 1655 (78%) | 1234 (77%) | 0.98 |
| Cam +ve | 294 (17%) | 335 (16%) | 289 (18%) | 0.94 |
| EuroSCORE 2 | ||||
| Cam −ve | 1.5 (1.4–1.54) | 1.6 (1.5–1.7) | 2.1 (1.9–2.2) | 0.55 |
| Cam +ve | 3.2 (2.7–3.8) | 2.5 (2.3–2.8) | 3.0 (2.8–3.5) | 0.64 |
| CPB (min) | ||||
| Cam −ve | 98 (95.0–100.0) | 96 (94.0–98.0) | 92 (89.7–93.3) | 0.91 |
| Cam +ve | 129 (121.6–134.4) | 111 (107.0–116.0) | 109 (102.1–113.9) | 0.35 |
| AOX (min) | ||||
| Cam −ve | 65 (63.0–65.0) | 63 (62.0–65.0) | 61 (59.0–63.0) | 0.94 |
| Cam +ve | 83 (75.3–88.0) | 74 (69.0–79.0) | 72 (68.0–76.0) | 0.64 |
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