Open Access
| Issue |
J Extra Corpor Technol
Volume 57, Number 4, December 2025
|
|
|---|---|---|
| Page(s) | 194 - 200 | |
| DOI | https://doi.org/10.1051/ject/2025025 | |
| Published online | 17 December 2025 | |
- Kinchin I, Mitchell E, Agar M, Trepel D, The economic cost of delirium: A systematic review and quality assessment. Alzheimers Dement. 2021;17(6):1026–1041. [Google Scholar]
- Mangusan RF, Hooper V, Denslow SA, Travis L, Outcomes associated with postoperative delirium after cardiac surgery. Am J Crit Care. 2015;24(2):156–163. [Google Scholar]
- Chen H, Mo L, Hu H, Ou Y, Luo J, Risk factors of postoperative delirium after cardiac surgery: a meta-analysis. J Cardiothorac Surg. 2021;16(1):113. [Google Scholar]
- Caldonazo T, Kirov H, Doenst T, Neurocognitive decline in cardiac surgery-Distraction rather than destruction? J Card Surg. 2022;37(1):148–150. [Google Scholar]
- Gosselt AN, Slooter AJ, Boere PR, Zaal IJ, Risk factors for delirium after on-pump cardiac surgery: a systematic review. Crit Care. 2015;19(1):346. [Google Scholar]
- Behrends M, DePalma G, Sands L, Leung J, Association between intraoperative blood transfusions and early postoperative delirium in older adults. J Am Geriatr Soc. 2013;61(3):365–370. [Google Scholar]
- Fatehi Hassanabad A, Bahrami N, Novick RJ, Ali IS, Delirium and depression in cardiac surgery: A comprehensive review of risk factors, pathophysiology, and management. J Card Surg. 2021;36(8):2876–2889. [Google Scholar]
- Kealy J, Murray C, Griffin EW, et al. Acute inflammation alters brain energy metabolism in mice and humans: role in suppressed spontaneous activity, impaired cognition, and delirium. J Neurosci, 2020;40(29):5681–5696. [Google Scholar]
- Lopez MG, Hughes CG, DeMatteo A, et al. Intraoperative oxidative damage and delirium after cardiac surgery. Anesthesiology. 2020;132(3):551–561. [Google Scholar]
- Myles PS, Smith JA, Painter T. Tranexamic acid in patients undergoing coronary-artery surgery. N Engl J Med. 2017;376(19):1893. [Google Scholar]
- Merino JG, Latour LL, Tso A, et al. Blood-brain barrier disruption after cardiac surgery. AJNR Am J Neuroradiol. 2013;34(3):518–523. [Google Scholar]
- Pang Y, Li Y, Zhang Y, et al. Effects of inflammation and oxidative stress on postoperative delirium in cardiac surgery. Front Cardiovasc Med. 2022;9:1049600. [Google Scholar]
- Majewski P, Zegan-Baranska M, Karolak I, Kaim K, Zukowski M, Kotfis K. Current evidence regarding biomarkers used to aid postoperative delirium diagnosis in the field of cardiac surgery – review. Medicina (Kaunas). 2020;56(10):493. [CrossRef] [Google Scholar]
- Rudolph JL, Ramlawi B, Kuchel GA, et al. Chemokines are associated with delirium after cardiac surgery. J Gerontol A Biol Sci Med Sci. 2008;63(2):184–189. [Google Scholar]
- Požgain Z, Dulic G, Kondza G, et al. Is postoperative cognitive decline after cardiac surgery associated with plasma beta amyloid 1–42 levels? J Cardiothorac Surg. 2022;17(1):6. [Google Scholar]
- Culkin MC, Bele P, Georges AP, et al. Early posttraumatic brain injury tranexamic acid prevents blood-brain barrier hyperpermeability and improves surrogates of neuroclinical recovery. J Trauma Acute Care Surg. 2023;95(1):47–54. [Google Scholar]
- Baker SK, Chen ZL, Norris EH, Revenko AS, MacLeod AR, Strickland S, Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci USA. 2018;115(41):E9687–E9696. [Google Scholar]
- Crash-3 Trial Collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet. 2019;394(10210):1713–1723. [CrossRef] [PubMed] [Google Scholar]
- Barrett CD, Kong YW, Yaffe MB. Influence of tranexamic acid on inflammatory signaling in trauma. Semin Thromb Hemost. 2020;46(2):183–188. [Google Scholar]
- Rui C, Dai G, Tian C, et al. Anti-inflammatory effect of multi-dose tranexamic acid in hip and knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials. Inflammopharmacology. 2025;33(3):917–928. [Google Scholar]
- Xie CM, Yao YT, He LX, Yang K, Evidence in Cardiovascular Anesthesia G. Anti-inflammatory effect of tranexamic acid on adult cardiac surgical patients: a PRISMA-compliant systematic review and meta-analysis. Front Surg. 2022;9:951835. [Google Scholar]
- Excellence NIfHaC. Quality statement 2: tranexamic acid for adults. NICE; 2016. Available at: https://www.nice.org.uk/guidance/qs138/chapter/quality-statement-2-tranexamic-acid-for-adults. Accessed September 14, 2024. [Google Scholar]
- Miranda F, Gonzalez F, Plana MN, Zamora J, Quinn TJ, Seron P, Confusion assessment method for the intensive care unit (CAM‐ICU) for the diagnosis of delirium in adults in critical care settings. Cochrane Database Syst Rev. 2023;11(11):CD013126. [Google Scholar]
- Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg. 2009;110(2):350–353. [Google Scholar]
- Karkouti K, Beattie WS, Dattilo KM, et al. A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery. Transfusion. 2006;46(3):327–338. [CrossRef] [PubMed] [Google Scholar]
- Grocott MPW, Murphy M, Roberts I, Sayers R, Toh CH, Tranexamic acid for safer surgery: the time is now. Br J Anaesth. 2022;129(4):459–461. [Google Scholar]
- Lecker I, Wang DS, Romaschin AD, Peterson M, Mazer CD, Orser BA. Tranexamic acid concentrations associated with human seizures inhibit glycine receptors. J Clin Invest. 2012;122(12):4654–4666. [Google Scholar]
- Hulde N, Zittermann A, Deutsch MA, von Dossow V, Gummert JF, Koster A, Tranexamic acid and convulsive seizures after isolated coronary artery bypass surgery: the role of cardiopulmonary bypass and renal function. Interact Cardiovasc Thorac Surg. 2020;30(4):538–540. [Google Scholar]
- Zufferey PJ, Lanoiselée J, Graouch B, Vieille B, Delavenne X, Ollier E. Exposure-response relationship of tranexamic acid in cardiac surgery: a model-based meta-analysis. Anesthesiology. 2021;134(2):165–178. [Google Scholar]
- Hulde N, Zittermann A, Deutsch MA, Gummert JF, von Dossow V, Koster A. Tranexamic acid and the risk of delirium after off-pump surgery. Thorac Cardiovasc Surg. 2024;72(1):51–54. [Google Scholar]
- Hulde N, Zittermann A, Gummert JF, von Dossow V, Koster A, Tranexamic acid and the risk of delirium after isolated “on-pump” coronary artery bypass grafting: a propensity score modeled analysis in 3392 patients. J Clin Anesth. 2021;74:110426. [Google Scholar]
- Lam T, Medcalf RL, Cloud GC, Myles PS, Keragala CB, Tranexamic acid for haemostasis and beyond: does dose matter? Thromb J. 2023;21(1):94. [Google Scholar]
- Atsev S, Tomov N. Using antifibrinolytics to tackle neuroinflammation. Neural Regen Res. 2020;15(12):2203–2206. [Google Scholar]
- Taylor J, Parker M, Casey CP, et al. Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study. Br J Anaesth. 2022;129(2):219–230. [Google Scholar]
- Terrando N, Akassoglou K. Breaking barriers in postoperative delirium. Br J Anaesth. 2022;129(2): 147–150. [Google Scholar]
- Song JX, Wu JX, Zhong H, Chen W, Zheng JC. Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med. 2024;32(1):18. [Google Scholar]
- Dean T, Mendiola AS, Yan Z, et al. Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation. J Neuroinflammation. 2024;21(1):94. [Google Scholar]
- Colomina MJ, Contreras L, Guilabert P, Koo M, Ndez EM, Sabate A. Clinical use of tranexamic acid: evidences and controversies. Braz J Anesthesiol. 2022;72(6):795–812. [Google Scholar]
- Ohashi N, Sasaki M, Ohashi M, Kamiya Y, Baba H, Kohno T. Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. Sci Rep. 2015;5:13458. [Google Scholar]
- Vu T, Smith JA. An update on postoperative cognitive dysfunction following cardiac surgery. Front Psychiatry. 2022;13:884907. [Google Scholar]
- Evans AS, Weiner MM, Arora RC, et al. Current approach to diagnosis and treatment of delirium after cardiac surgery. Ann Card Anaesth. 2016;19(2):328–337. [Google Scholar]
- Koster S, Hensens AG, Schuurmans MJ, van der Palen J. Risk factors of delirium after cardiac surgery: a systematic review. Eur J Cardiovasc Nurs. 2011;10(4):197–204. [Google Scholar]
- Myles PS. Tranexamic acid to reduce delirium after gastrointestinal surgery: the TRIGS-D trial sub-study of the TRIGS trial., TRIGS, Available at: https://www.trigs.org.au/trigs_d. Accessed September 14, 2024. [Google Scholar]
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.
