Issue |
J Extra Corpor Technol
Volume 15, Number 5, October 1983
|
|
---|---|---|
Page(s) | 126 - 132 | |
DOI | https://doi.org/10.1051/ject/1983155126 | |
Published online | 18 September 2023 |
Proceedings
Conversion of Dilute Pump Blood to Whole Blood by Single Pass Ultrafiltration
1
Division of Cardiovascular Surgery, Department of Surgery, North Shore University Hospital, Manhasset, New York
2
Department of Surgery, Cornell University Medical College, New York
* Direct communications to: Yehuda Tamari, Division of Cardiovascular Surgery, North Shore University Hospital, Manhasset, NY 11030.
Ultrafiltration (UF) effectively reverses hemodilution. However, when used to concentrate pump blood post-bypass, the recirculation method does not make concentrated blood available until all the blood has been processed. To make concentrated whole blood immediately available, we have investigated the use of a single pass ultrafiltration (SPUF) technique in 7 patients. By reducing the blood flow, the concentration of the blood components at the outlet of the ultrafilter (UF) was sufficient to allow direct transfusion. After bypass, the blood in the oxygenator (1664 ± 112 ml) was pumped (153 ± 12 mllmin) through an UF device and into a transfusion bag. Suction (- 480 torr) applied to the device extracted plasma water (82 ± 3 ml/min). SPUF concentrated the diluted pump blood as follows (mean ± standard error of the means): WBC from 8.5 ± 1.2 to 16.3 ± 2.5 × 103/ul, hemoglobin (6.5 ± 0.2 to 13.2 ± 0.5 gr/dl), platelets (135 ± 14 to 224 ± 32 × 103/ul), albumin (2.9 ± 0.2 to 7.6 ± 0.6 gr/dl) and fibrinogen (114 ± 9 to 274 ± 26 mg/dl). For heparin neutralized plasma, there was a decrease towards normal in prothrombin time (17.9 ± 0.6 to 14.1 ± 0.3 sec) and activated partial thromboplastin time (46 ± 2 to 32 ± 2 sec). There was no net increase in plasma free homoglobin. Red cell indices tended to normalize. Following transfusion of the concentrated blood there were increases in albumin (3.4 ± 0.2 to 3.9 ± 0.2 gr/dl) and hemoglobin (8.5 ± 0.6 to 9.5 ± 0.6 gr/dl). There were no statistically significant changes in white blood cells, platelets, prothrombin and activated partial thromboplastin time. Conclusion: SPUF is an efficient, useful, safe, simple and rapid method for obtaining whole blood for immediate transfusion.
© 1983 AMSECT
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