Issue |
J Extra Corpor Technol
Volume 21, 1989
Proceedings of AmSECT’s 27th International Conference
|
|
---|---|---|
Page(s) | 104 - 110 | |
DOI | https://doi.org/10.1051/ject/198921S104 | |
Published online | 24 August 2023 |
Original Article
Does Plasma Sequestration Reduce Post-Operative Bleeding?
Departments of Surgery and Anesthesia, Cooper HospitaVUniversity Medical Center, School of Cardiovascular Perfusion, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School of Camden, Camden, NJ
* Address correspondence to: Anthony J. DelRossi, M.D., Department of Surgery, Cooper Hospital/University Medical Center, Three Cooper Plaza, Suite 411, Camden, NJ, 08103
Hematologic profiles, postoperative blood loss and transfusion requirements were studied in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) in order to determine the effect of sequestration and reinfusion of platelet-rich plasma (PRP). Eighteen patients were randomly selected to have approximately one unit of PRP collected or not prior to CPB. Autologous PRP was reinfused in nine patients after reversal of anticoagulation. Evaluation of results was based upon thrombocyte counts, Hgb, Hct, and platelet index readings pre- and post-PRP reinfusion, amount of blood loss and volumes of homologous blood and banked blood products required postoperatively. There were no hemodynamic complications related to the sequestration process. PRP reinfused patients had significantly higher thrombocyte counts after reversal of anticoagulation (p < 0.05). Patients receiving PRP required approximately 2/3 less banked blood products, their bleeding being significantly reduced 24 hours postoperatively (p < 0.05). We concluded that plasma sequestration and reinfusion of autologous PRP post-bypass may serve as an effective and safe way in decreasing blood loss after cardiac operations necessitating extracorporeal circulation.
Key words: Cardiopulmonary bypass / hemorrhage / plasma saving system / platelet blood transfusion
© 1989 AMSECT
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.