Issue |
J Extra Corpor Technol
Volume 22, 1990
Proceedings of AmSECT’s 28th International Conference
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Page(s) | 27 - 29 | |
DOI | https://doi.org/10.1051/ject/199022S027 | |
Published online | 23 August 2023 |
Original Article
A Clinical Evaluation of the Correlation and Reprodicibility Of Three Automated Devices For Measurement of Activated Clotting Times
The Ohio State University Hospital, Columbus, OH
* Address correspondence to: Mark Dumond, BS, CCT, Department of Circulation Technology 480 Doan Hall, 410 West Tenth Ave. Columbus, Ohio 43210
The Activated Clotting Time (ACT) assumes an important role in documentation of adequacy of perfusion. Therefore, it is important to document the correlation and reproducibility of automated systems currently available to measure the ACT value. During surgical procedures of 37 patients requiring cardiopulmonary bypass a blood sample was drawn in a single syringe and ACT values obtained using four Hemotec ACTs (T-ACT), four Hemochron ACTs (M-ACT), and two Sonoclot ACTs (S-ACT). Sample points with the mean of two of the three sets of ACTs exceeding 650 were excluded and the values were divided into heparinized (ACTH) (n=44) and nonheparinized (ACTN) (n=58) groups.
Group | Mean Value | Avg. Std. Dev. | r 2/T-ACTN | r w/H-ACTN | r w/T-ACTH | r w/H-ACTH |
T-ACTN | 104 | 3 | - | .638 | - | - |
H-ACTN | 128 | 5 | .638 | - | - | - |
S-ACTN | 138 | 11 | .663 | .580 | - | - |
T-ACTH | 551 | 48 | - | - | - | .224 |
M-ACTH | 514 | 69 | - | - | .224 | - |
S-ACTH | 768 | 98 | - | - | .041 | .244 |
The very poor correlation of the three systems raises doubts as to interchangeability of ACT values from each system. The reproducibility (based on the size of the STD. DEV.) of the Hemotec system is significantly better than the Sonoclot.
Key words: Activated clotting time / cardiopulmonary bypass / anticoagulation monitoring / reproducibility
© 1990 AMSECT
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