Issue |
J Extra Corpor Technol
Volume 22, 1990
Proceedings of AmSECT’s 28th International Conference
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Page(s) | 30 - 34 | |
DOI | https://doi.org/10.1051/ject/199022S030 | |
Published online | 23 August 2023 |
Original Article
Clinical Evaluation of the Hemotec Heparin Dose Response Cartridge
The Ohio State University Hospital, Columbus, OH
* Address correspondence to: Mark Dumond, BS, CCT, Department of Circulation Technology 480 Doan Hall, 410 West Tenth Ave. Columbus, Ohio 43210
The intent of this study is to evaluate the ability of the Hemotec System Four to provide an accurate predictor of heparin requirements for patients undergoing cardiopulmonary bypass (CPB). The study group consisted of 27 consecutive patients undergoing CPB. Patient charts were reviewed for preoperative use of heparin or IV nitroglycerin therapy. Blood samples were drawn prior to induction of anesthesia and an Activated Clotting Time (ACT) obtained from a Hemochron 400 along with the heparin maintenance level (HML) in units/Kg and slope in sec/mg/kg obtained from the Hemotec System Four. Following heparinization of the patient at 300 units/kg an ACT was performed prior to initiation of CPB and additional heparin given if the value failed to reach at least 480 seconds. The amount of heparin (AHL) needed to reach an ACT of 480 seconds was calculated from a dose response curve utilizing the final heparin dose, the initial ACT, and the final ACT. The correlation of the HML and the AHL was .547. The correlation of the slope value to AHL was -.596. The level of false negative responses obtained from the HML or the slope value were not significantly different from the levels achieved from use of pre-operative heparin or IV nitroglycerin therapy as an indicator of heparin resistance. The heparin dose response system did not improve our ability to predict the individual patients heparin requirements.
Key words: Activated clotting time / cardiopulmonary bypass / anticoagulation monitoring / heparin dose response
© 1990 AMSECT
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