Issue |
J Extra Corpor Technol
Volume 30, Number 3, September 1998
|
|
---|---|---|
Page(s) | 115 - 119 | |
DOI | https://doi.org/10.1051/ject/1998303115 | |
Published online | 14 August 2023 |
Original Article
Experimental Evaluation of the Medtronic Maxima Forte Hollow Fiber Membrane Oxygenator
Clinic for Cardiovascular Surgery, CHUV (Centre Hospitalier Universitaire Vaudois), Lausanne, Switzerland
* Address correspondence to: Dr. X. Mueller Clinic for Cardiovascular Surgery CHUV (Centre Hospitalier Universitaire Vaudois) CH-1 011 Lausanne, Switzerland
A new hollow fiber membrane oxygenator, the Medtronic Maxima Forté, was tested for gas transfer, blood path resistance and blood handling characteristics in a standardized setting with surviving animals.
Three calves (mean body weight: 71±9.6 kg) were placed on cardiopulmonary bypass at a mean flow rate of 50 ml/kg/min for six hours. The circuit included the Maxima Forté oxygenator. The animals were weaned from cardiopulmonary bypass and then from the ventilator. After seven days, the animals were sacrificed electively.
Physiologic blood gas values could be maintained throughout perfusion in all animals. Mean pressure drop through the oxygenator varied between 49 mmHg and 66 mmHg. The respective baseline values for red blood cell count, white blood cell count and platelets were 8.90±1.26 106/mm3, 7.46±3.17 103/mm3 · and 680±216 l03/mm3. Red blood cell and platelet counts dropped slightly to 7.26±1.61 106/mm3 and 400±126 l03/mm3 at the end of the bypass, whereas the white blood cell count increased up to 9.13±5.25 103/mm3. All three cell lines returned to near their baseline values after seven days. Blood trauma evaluated as a function of plasma hemoglobin (plasma Hb) and lactate dehydrogenase (LDH) showed stable values during all the perfusion time. Both peaked at 24 hours before returning to their baseline values at seven days. LDH showed a statistically significant variation: 3255 ± 693 IU at 24 hours versus 2029 ± 287 IU at baseline (p = 0.04). The variation of plasma Hb was not statistically significant (93.5 ± 7.7 µmol/1 at 24 hours versus 77.3 ± 52.3 µmol/1 at baseline) indicating a weak effect of the perfusion on blood trauma.
The Medtronic Maxima Forté hollow fiber membrane oxygenator offered good gas exchange capabilities, a low pressure drop, and low blood trauma over a prolonged perfusion time of six hours in this evaluation.
Key words: cardiopulmonary bypass / materials testing / hollow fiber membrane oxygenator
© 1998 AMSECT
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.