Issue |
J Extra Corpor Technol
Volume 32, Number 3, September 2000
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|
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Page(s) | 152 - 157 | |
DOI | https://doi.org/10.1051/ject/2000323152 | |
Published online | 14 August 2023 |
Original Article
Impact of Hollow-Fiber Membrane Surface Area on Oxygenator Performance: Dideco D903 Avant Versus a Prototype with Larger Surface Area
Clinic for Cardiovascular Surgery, CHUV (Centre Hospitalier Universitaire Vaudois), Switzerland
* Address correspondence to: X. Mueller, MD Clinic for Cardiovascular Surgery CHUV (Centre Hospitalier Universitaire Vaudois) CH-1011 Lausanne Switzerland e-mail: Xavier.Mueller@chuv.hospvd.ch
This study compares the gas transfer capacity, the blood trauma, and the blood path resistance of the hollow-fiber membrane oxygenator Dideco D 903 with a surface area of 1.7 m2 (oxygenator 1.7) versus a prototype built on the same principles but with a surface area of 2 m2 (oxygenator 2).
Six calves (mean body weight: 68.2 ± 3.2 kg) were connected to cardiopulmonary bypass (CPB) by jugular venous and carotid arterial cannulation, with a mean flow rate of 4l/min for 6 h. They were randomly assigned to oxygenator 1.7 (N = 3) or 2 (N = 3). After 7 days, the animals were sacrificed. A standard battery of blood samples was taken before the bypass, throughout the bypass, and 24 h, 48 h, and 7 days after the bypass.
The oxygenator 2 group showed significantly better total oxygen and carbon dioxide transfer values throughout the perfusion (p < .001 for both comparison). Hemolytic parameters (lactate dehydrogenase and free plasma hemoglobin) exhibited a slight but significant increase after 5 h of bypass in the oxygenator 1.7 group. The pressure drop through the oxygenator was low in both groups (range, 43–74 mmHg).
With this type of hollow-fiber membrane oxygenator, an increased surface of gas exchange from 1.7m2 to 2 m2 improves gas transfer, with a limited impact on blood trauma and no increase of blood path resistance.
Key words: cardiopulmonary bypass / oxygenator / blood–air barrier
© 2000 AMSECT
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