Issue |
J Extra Corpor Technol
Volume 41, Number 3, September 2009
|
|
---|---|---|
Page(s) | 140 - 148 | |
DOI | https://doi.org/10.1051/ject/200941140 | |
Published online | 15 September 2009 |
Review Article
Perfusion Preservation of the Donor Heart: Basic Science to Pre-Clinical
* Department of Surgery, Experimental Surgical Services, University of Minnesota, Minneapolis, Minnesota
† Department of Radiology, University of Florida, Gainesville, Florida
‡ Department of Surgery, Brigham and Women’s Hospital, Boston, Massachusetts
§ Department of Neuroscience, University of Dublin, Trinity College, Institute of Neuroscience, Dublin, Ireland
Address correspondence to: Andrew L. Rivard, MD, MS, Department of Radiology, University of Florida, PO Box 103462, Gainesville, FL 32610-0374. E-mail: rivar011@umn.edu
Received:
22
February
2009
Accepted:
1
August
2009
As a consequence of technology improvements and refinement, perfusion of the donor heart has moved from the research laboratory to clinical studies. Multiple investigators are currently leading pre-clinical trials of devices using perfusion preservation, and one device is now in European clinical trials. One major problem with the donor heart is the high metabolism relative to other organs, and depletion of ATP leads rapidly to acidosis and necrosis of the myocardium. Two techniques in development to address the issue are normothermic and hypothermic perfusion. This review examines the current issues regarding donor heart preservation and techniques of pre-clinical evaluation necessary for regulatory approval.
Key words: cardiac transplant / donor heart / myocardial protection
© 2009 AMSECT
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