Guest Editorial

History and Use of del Nido Cardioplegia Solution at Boston Children’s Hospital

Address correspondence to: Gregory S. Matte, BS, CCP, LP, Perfusion Clinical Coordinator, Department of Cardiac Surgery, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115. E-mail: gregory.matte@cardio.chboston.org

Received: 22 May 2012
Accepted: 18 July 2012

Abstract

Cardioplegia is an integral and essential method of myocardial protection for patients of all ages requiring cardiac surgery in which the heart must be stopped. Numerous cardioplegia solutions and delivery methods have been developed. The del Nido cardioplegia solution has been in use for 18 years at Boston Children’s Hospital. This is a unique four parts crystalloid to one part whole blood formulation that is generally used in a single-dose fashion. Although the formulation was originally developed for use in pediatric and infant patients, its use for adult cardiac surgery has been expanding. National and international inquiries to our institution regarding this cardioplegia have been increasing over the last 2 years. We present the developmental history, supporting theory, and current protocol for use of what is now referred to as del Nido cardioplegia.