Issue |
J Extra Corpor Technol
Volume 42, Number 1, March 2010
|
|
---|---|---|
Page(s) | 20 - 29 | |
DOI | https://doi.org/10.1051/ject/201042020 | |
Published online | 15 March 2010 |
Abstract
Application of Autologous Derived-Platelet Rich Plasma Gel in the Treatment of Chronic Wound Ulcer: Diabetic Foot Ulcer
* Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
† Department of Clinical Perfusion Science, St. Bartholomew Hospital, West Smith Field, London, United Kingdom
‡ Microvascular Unit, Ernest Cooke Laboratory, St. Bartholomew Hospital, West Smith Field, London, United Kingdom
§ Vascular Surgery Unit, Department of General Surgery, Barts and The London Hospitals, NHS Trust, Whitechapel, London, United Kingdom
Address correspondence to: Akinfemi Ayobami Akingboye, Vascular Surgery Unit, Department of General Surgery, Barts and The London School of Medicine and Dentistry, White Chapel, London, E1 1BB. E-mail: akinfemi.akingboye@bartsandthelondon.nhs.uk
Received:
23
October
2008
Accepted:
27
September
2009
The treatment of chronic wounds remains problematic, despite new insight into the cellular and molecular basis of wound healing. Although the aetio-pathogenesis of chronic wounds is said to be multi-factorial, it is evident from literature that effective and adequate wound debridement has produced the most consistent effect in chronic wound treatment. There is a growing body of evidence that suggests that wound healing in chronic diabetic foot ulcers is growth factor dependent and that the therapeutic delivery of these growth factors to wounds topically, has the potential ability to accelerate wound healing in conjunction with conventional wound care. Autologous derived platelet concentrate is activated to release growth factors that are stored in the platelet granules. These secretory proteins include cytokines and growth factors such as transforming growth factor–beta, vascular endothelia growth factor, platelet derived growth factor, and so on. The enhancement of soft tissue healing by the application of autologous derived platelet rich plasma gel (APG) is supported by basic science and some clinical studies. This review article will attempt to provide a concise report of current concepts on the use of APG in treating chronic ulcers.
Key words: autologous derived platelet rich plasma / diabetic foot ulcer / growth factors / wound healing
© 2010 AMSECT
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