Determining the association of hyperoxia while on extracorporeal life support with mortality in neonates following Norwood operation

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Table 6

Outcomes of neonates requiring extracorporeal life support post-Norwood operation using univariable and multivariable regression analysis.

Variables	Non-hyperoxia Group	Hyperoxia Group	OR (95% CI)	p-value	aOR^a (95% CI)	Adjusted p-value
Variables	Median PaO₂ ≤ 182 (n = 31)	Median PaO₂ > 182 (n = 34)	OR (95% CI)	p-value	aOR^a (95% CI)	Adjusted p-value
Stage II or III AKI	17 (54.8%)	18 (52.9%)	0.93 (0.35, 2.46)	0.878	1.38 (0.37, 5.13)	0.634
PPLOS^b	12 (38.7%)	5 (14.7%)	0.27 (0.08, 0.9)	0.033	0.41 (0.09, 1.76)	0.229
Operative death	12 (38.7%)	26 (76.5%)	5.15 (1.76, 15.04)	0.003	3.11 (0.79, 12.26)	0.104

Adjusted for source of pulmonary blood flow, CPB time, and post-Norwood VIS-score at 48 hours.

Third quartile of postoperative length of stay (≥55) was applied as cutoff.

Abbreviations: PaO₂: Partial Pressure of Oxygen; AKI: Acute Kidney Injury; PPLOS: Prolonged Postoperative Length of Stay.

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