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Table 1
Patient demographics and clinical characteristics of entire VV-ECLS cohort stratified by median PaO2 levels in the first 48 h in to non-hyperoxia group (PaO2 ≤ 122 mmHg) and hyperoxia group (PaO2 > 122 mmHg).
| Variables | Total cohort (n = 110) | Non-hyperoxia group (PaO2 ≤ 122 mmHg) (n = 87) | Hyperoxia group (PaO2 > 122 mmHg) (n = 23) | p-value |
|---|---|---|---|---|
| Age (months) | 4.9 (0.1, 105.4) | 1.6 (0.0, 81.7) | 105.4 (3.4, 154.4) | 0.001 |
| Age group | 0.003 | |||
| Neonatal | 63 (57.3%) | 56 (64.4%) | 7 (30.4%) | |
| Pediatrics | 47 (42.7%) | 31 (35.6%) | 16 (69.6%) | |
| Weight (kg) | 5.4 (3.4, 35.0) | 4.3 (3.2, 22.0) | 28.3 (5.0, 81.2) | 0.002 |
| Height (cm) | 69.0 (51.0, 139.0) | 56.0 (51.0, 127.0) | 128.0 (73.4, 170.0) | 0.005 |
| BSA (m2) | 0.4 (0.2, 1.2) | 0.3 (0.2, 1.1) | 1.4 (0.4, 2.0) | 0.005 |
| Race | 0.230 | |||
| Black | 57 (51.8%) | 41 (47.1%) | 16 (69.6%) | |
| White | 38 (34.5%) | 32 (36.8%) | 6 (26.1%) | |
| Hispanic | 12 (10.9%) | 11 (12.6%) | 1 (4.3%) | |
| Other | 3 (2.7%) | 3 (3.4%) | 0 (0.0%) | |
| Sex | 0.194 | |||
| Female | 58 (53.2%) | 43 (50.0%) | 15 (65.2%) | |
| Male | 51 (46.8%) | 43 (50.0%) | 8 (34.8%) | |
| ECLS indication | 0.001 | |||
| Cardiac | 8 (7.3%) | 4 (4.6%) | 4 (17.4%) | |
| ECPR | 8 (7.3%) | 3 (3.4%) | 5 (21.7%) | |
| Pulmonary | 94 (85.5%) | 80 (92.0%) | 14 (60.9%) | |
| Time from admission to ECLS Initiation | 39.0 (3.0, 116.0) | 24.0 (2.5, 102.0) | 40.0 (3.0, 116.0) | 0.560 |
| Initial ECLS flow (L/min) | 0.5 (0.4, 2.8) | 0.4 (0.4, 1.8) | 2.9 (0.7, 4.5) | 0.001 |
| Mand PaO2 (SD) | 97.7 (46.64) | 79.2 (23.4) | 167.5 (46.8) | <0.001 |
| Median PaO2 (mmHg) | 86.6 (62.9, 114.6) | 77.4 (59.9, 100.5) | 159.9 (129.7, 202.2) | <0.001 |
| PaO2 range (mmHg) | 37.2–277.8 | 37.2–120.8 | 122.5–277.8 | <0.001 |
| Number of PaO2 samples per patient | ||||
| Mean (SD) | 13.3 (4.21) | 12.5 (3.97) | 16.2 (3.87) | <0.001 |
| Median (IQR) | 12.0 | 12.0 | 16.0 | <0.001 |
| Duration of ECLS run (hours) | 140.5 (98.0, 287.0) | 146.0 (98.0, 289.0) | 136.0 (89.0, 205.0) | 0.549 |
| ECLS complications | ||||
| Cardiovascular | 40 (40.8%) | 28 (37.3%) | 12 (52.2%) | 0.203 |
| Hemorrhagic | 35 (35.7%) | 19 (25.3%) | 16 (69.6%) | 0.0001 |
| Mechanical | 57 (58.2%) | 43 (57.3%) | 14 (60.9%) | 0.764 |
| Renal | 67 (68.4%) | 48 (64.0%) | 19 (82.6%) | 0.093 |
| Neurologic | 14 (14.3%) | 11 (14.7%) | 3 (13.0%) | 0.846 |
| Metabolic | 20 (20.4%) | 15 (20.0%) | 5 (21.7%) | 0.856 |
| Infection | 3 (3.1%) | 3 (4.0%) | 0 (0.0%) | 0.330 |
| Reason for coming off | ||||
| Died or poor prognosis | 21 (19.1%) | 11 (12.6%) | 10 (43.5%) | 0.001 |
| ECLS complication | 6 (5.5%) | 6 (6.9%) | 0 (0.0%) | |
| Expected recovery | 80 (72.7%) | 69 (79.3%) | 11 (47.8%) | |
| VAD | 3 (2.7%) | 1 (1.1%) | 2 (8.7%) | |
| AKI stage II/III | 61 (64.9%) | 50 (66.7%) | 11 (57.9%) | 0.474 |
| Mortality | 29 (26.4%) | 17 (19.5%) | 12 (52.2%) | 0.002 |
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