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Table 5
Externally validated VA ECMO scores with statistical information.
| Score name | Study | Tested patient population | Statistical Info |
|---|---|---|---|
| SAVE score | Schmidt et al. [26] (n = 3846) | – Adult VA ECMO patients | Internal validation: |
| – c-statistic (95% CI): 0.68 (0.66–0.69) | |||
| – O:E ratio (95% CI): 0.99 | |||
| Pladet et al. [45] (n = N/A) | – Adult VA ECMO patients, including ECPR | External validation (ECPR): | |
| – c-statistic (95% CI): 0.70 (0.64–0.75) in pooled analysis | |||
| – O: E ratio (95% CI): 1.15 (0.88–1.49) in pooled analysis | |||
| – Adult VA ECMO patients excluding ECPR | External validation (no ECPR): | ||
| – c-statistic (95% CI): 0.74 (0.59–0.84) | |||
| – O:E ratio (95% CI): 1.13 (0.70–1.80) | |||
| Schmidt et al. [26] (n = 161) | – Adult VA ECMO patients except PC and ECPR | External validation: | |
| AUROC: 0.90 (95% CI: 0.85–0.95) | |||
| Amin et al. [28] (n = 120) | – Adult VA ECMO patients for refractory CS and ECPR | External validation: | |
| – Survivors vs. non-survivors SAVE score: | |||
| −9.3 ± 4.1 vs. −13.1 ± 4.4, p = 0.001 | |||
| – c-statistic (95% CI): 0.77 (0.69–0.86), p < 0.001 | |||
| – limited predictive value: survival rates by SAVE score class: II: 67% vs. 58%, III: 78% vs. 42%, IV: 61% vs. 30%, V: 29% vs. 18% | |||
| Modified SAVE score | Chen et al. [29] (n = 154) | – Emergency department adult VA ECMO – includes ECPR, excludes PC ECMO | External validation: |
| – SAVE +lactate: AUROC: 0.84 | |||
| Santore et al. [50] (n = 126) | – Adult VA ECMO cardiac arrest patients, CS, PC ECMO | External validation: | |
| – All indications c-statistic (95% CI): c = 0.736 (0.643–0.829), p < 0.001 | |||
| – Excluding PC ECMO c-statistic (95% CI): c = 0.744 (0.645–0.844), p < 0.001 | |||
| PREDICT VA-ECMO (6-h and 12-h) | Wengenmayer et al. [30] | – all adult VA ECMO patients | External validation: |
| − 6 h of ECMO: AUROC (95% CI): 0.718 (0.65–0.78) | |||
| − 12 h of ECMO: AUROC (95% CI): 0.735 (0.65–0.82) |
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