Open Access
Issue
J Extra Corpor Technol
Volume 38, Number 1, March 2006
Page(s) 52 - 56
DOI https://doi.org/10.1051/ject/200638052
Published online 15 March 2006
  1. Merry A, Raudkivi P, Middleton N, et al. Bivalirudin versus heparin and protamine in off pump coronary bypass surgery. Ann Thorac Surg. 2004;77:925–31. [CrossRef] [Google Scholar]
  2. Gibbon JHJ. The development of the heart-lung apparatus. Am J Surg. 1978;135:608–19. [CrossRef] [Google Scholar]
  3. Nunley RM, Lachiewicz PF. Mortality after total hip and knee arthroplasty in a medium-volume university practice. Journal of Arthroplasty. 2003;18:278–85. [CrossRef] [Google Scholar]
  4. Charlesworth DC, Likosky DS, Marrin CA, et al. Development and validation of a prediction model for strokes after coronary artery bypass grafting. Ann Thorac Surg. 2003;76:436–43. [CrossRef] [Google Scholar]
  5. Engoren MC, Habib RH, Zacharias A, et al. Effect of blood transfusion on long-term survival after cardiac operation. Ann Thorac Surg. 2002;74:1180–6. [CrossRef] [Google Scholar]
  6. Spiess BD. Blood transfusion: the silent epidemic. Ann Thorac Surg. 2001;72:S1832–7. [CrossRef] [Google Scholar]
  7. Spiess BD. Heparin: beyond an anticoagulant, The relationship between coagulation, inflammation, and endothelium. Edited by Spiess BD. Baltimore, 2000, pp. 169–90. [Google Scholar]
  8. Bauer TL, Arepally G, Konkle BA, et al. Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. Circulation. 1997;95:1242–6. [CrossRef] [PubMed] [Google Scholar]
  9. Weitz JI, Crowther M. Direct thrombin inhibitors. Thrombosis Research. 2002;106:V275–84. [CrossRef] [PubMed] [Google Scholar]
  10. Spiess BD. Transfusion and outcome in heart surgery. Ann Thorac Surg. 2002;74:986–7. [CrossRef] [Google Scholar]
  11. Williams RT, Damaraju LV, Mascelli MA, et al. Anti-platelet factor 4/heparin antibodies: an independent predictor of 30-day myocardial infarction after acute coronary ischemic syndromes. Circulation. 2003;107:2307–12. [CrossRef] [PubMed] [Google Scholar]
  12. Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med. 1995;332:1330–5. [CrossRef] [PubMed] [Google Scholar]
  13. Pouplard C, May MA, Iochmann S, et al. Antibodies to platelet factor 4-heparin after cardiopulmonary bypass in patients anticoagulated with unfractionated heparin or a low-molecular-weight heparin: clinical implications for heparin-induced thrombocytopenia. Circulation. 1999;99:2530–6. [CrossRef] [PubMed] [Google Scholar]
  14. Mattioli AV, Bonetti L, Sternieri S, Mattioli G. Heparin-induced thrombocytopenia in patients treated with unfractionated heparin: prevalence of thrombosis in a 1 year follow-up. Ital Heart J. 2000;1:39–42. [Google Scholar]
  15. Simoons ML. GUSTO IV-ACS Investigators: Effect of glycoprotein IIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation: the GUSTO IV-ACS randomised trial. Lancet. 2001;357:1915–24. [CrossRef] [PubMed] [Google Scholar]
  16. Newman PM, Swanson RL, Chong BH. Heparin-induced thrombocytopenia: IgG binding to PF4-heparin complexes in the fluid phase and cross-reactivity with low molecular weight heparin and heparinoid. Thrombosis & Haemostasis. 1998;80:292–7. [CrossRef] [PubMed] [Google Scholar]
  17. Bates SM, Weitz JI. Direct thrombin inhibitors for treatment of arterial thrombosis: potential differences between bivalirudin and hirudin. Am J Cardiol. 1998;82:12P–8P. [CrossRef] [Google Scholar]
  18. Butterworth J, Lin YA, Prielipp RC, et al. Rapid disappearance of protamine in adults undergoing cardiac operation with cardiopulmonary bypass. Ann Thorac Surg. 2002;74:1589–95. [CrossRef] [Google Scholar]
  19. Kimmel SE, Sekeres M, Berlin JA, Ellison N. Mortality and adverse events after protamine administration in patients undergoing cardiopulmonary bypass. Anesth Analg. 2002;94:1402–8. [CrossRef] [PubMed] [Google Scholar]
  20. Physician’s Desk Reference. Protamine, 2000. [Google Scholar]
  21. Frederiksen JW. Cardiopulmonary bypass in humans: bypassing unfractionated heparin. Ann Thorac Surg. 2000;70:1434–43. [CrossRef] [Google Scholar]
  22. Weitz JI. Low-molecular-weight heparins. New England Journal of Medicine. 1997;337:688–98. [CrossRef] [PubMed] [Google Scholar]
  23. Massonnet-Castel S, Pelissier E, Bara L, et al. Partial reversal of low molecular weight heparin (PK 10169) anti-Xa activity by protamine sulfate: in vitro and in vivo study during cardiac surgery with extracorporeal circulation. Haemostasis. 1986;16:139–46. [PubMed] [Google Scholar]
  24. Newman PM, Chong BH. Heparin-induced thrombocytopenia: new evidence for the dynamic binding of purified anti-PF4-heparin antibodies to platelets and the resultant platelet activation. Blood. 2000;96:182–7. [CrossRef] [PubMed] [Google Scholar]
  25. Doherty DC, Ortel TL, de Bruijn N, Greenberg CS, Van Trigt P3rd. “Heparin-free” cardiopulmonary bypass: first reported use of heparinoid (Org 10172) to provide anticoagulation for cardiopulmonary bypass. Anesthesiology. 1990;73:562–5. [CrossRef] [PubMed] [Google Scholar]
  26. Illig KA, Ouriel K. Ancrod: understanding the agent. Seminars in Vascular Surgery. 1996;9:303–14. [PubMed] [Google Scholar]
  27. Brieger DB, Mak KH, Kottke-Marchant K, Topol EJ. Heparin-induced thrombocytopenia. Journal of the American College of Cardiology. 1998;31:1449–59. [CrossRef] [PubMed] [Google Scholar]
  28. Walls JT, Curtis JJ, Silver D, et al. Heparin-induced thrombocytopenia in open heart surgical patients: sequelae of late recognition. Ann Thorac Surg. 1992;53:787–91. [CrossRef] [Google Scholar]
  29. Laster J, Elfrink R, Silver D. Reexposure to heparin of patients with heparin-associated antibodies. J Vasc Surg. 1989;9:677–82. [CrossRef] [Google Scholar]
  30. Koster A, Kukucka M, Bach F, et al. Anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II and renal impairment using heparin and the platelet glycoprotein IIb-IIIa antagonist tirofiban. Anesthesiology. 2001;94:245–51. [CrossRef] [PubMed] [Google Scholar]
  31. Koster A, Meyer O, Fischer T, et al. One-year experience with the platelet glycoprotein IIb/IIIa antagonist tirofiban and heparin during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II. Journal of Thoracic & Cardiovascular Surgery. 2001;122:254–5. [Google Scholar]
  32. Potzsch B, Klovekorn WP, Madlener K. Use of heparin during cardiopulmonary bypass in patients with a history of heparin-induced thrombocytopenia. New England Journal of Medicine. 2000;343:515. [CrossRef] [PubMed] [Google Scholar]
  33. Greinacher A, Lubenow N, Eichler P. Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with Heparin-Induced Thrombocytopenia. Ciruclation. 2003;108:2062–5. [CrossRef] [PubMed] [Google Scholar]
  34. Nowak G, Bucha E. Prothrombin conversion intermediate effectively neutralizes toxic levels of hirudin. Thrombosis Research. 1995;80:317–25. [CrossRef] [PubMed] [Google Scholar]
  35. Koster A, Kuppe H, Hetzer R, et al. Emergent cardiopulmonary bypass in five patients with heparin-induced thrombocytopenia type II employing recombinant hirudin. Anesthesiology. 1998;89:777–80. [CrossRef] [PubMed] [Google Scholar]
  36. Fischer BE, Schlokat U, Himmelspach M, Dorner F. Binding of hirudin to meizothrombin. Protein Engineering. 1998;11:715–21. [CrossRef] [Google Scholar]
  37. Koster A, Chew D, Grundel M, et al. Bivalirudin monitored with the ecarin clotting time for anticoagulation during cardiopulmonary bypass. Anesthesia & Analgesia. 2003;96:383–6. [Google Scholar]
  38. Hursting MJ, Alford KL, Becker JC, et al. Novastan (brand of argatroban): a small-molecule, direct thrombin inhibitor. Seminars in Thrombosis & Hemostasis. 1997;23:503–16. [CrossRef] [PubMed] [Google Scholar]
  39. Lubenow N, Selleng S, Wollert HG, et al. : Heparin-induced thrombocytopenia and cardiopulmonary bypass: perioperative argatroban use. Ann Thorac Surg 2003;75:577–9. [CrossRef] [PubMed] [Google Scholar]
  40. Edwards JT, Hamby JK, Worrall NK. Successful use of Argatroban as a heparin substitute during cardiopulmonary bypass: heparin-induced thrombocytopenia in a high-risk cardiac surgical patient. Ann Thorac Surg. 2003;75:1622–4. [CrossRef] [Google Scholar]
  41. Furukawa K, Ohteki H, Hirahara K, Narita Y, Koga S. The use of argatroban as an anticoagulant for cardiopulmonary bypass in cardiac operations. Journal of Thoracic & Cardiovascular Surgery. 2001;122:1255–6. [CrossRef] [Google Scholar]
  42. Robson R, White H, Aylward P, Frampton C. Bivalirudin pharmacokinetics and pharmacodynamics: effect of renal function, dose, and gender. Clinical Pharmacology & Therapeutics. 2002;71:433–9. [CrossRef] [PubMed] [Google Scholar]
  43. Fox I, Dawson A, Loynds P, et al. Anticoagulant activity of Hirulog, a direct thrombin inhibitor, in humans. Thrombosis & Haemostasis. 1993;69:157–63. [CrossRef] [PubMed] [Google Scholar]
  44. White H. Hirulog, Early Reperfusion or Occlusion -2 Trial I: Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial. Lancet. 2001;358:1855–63. [Google Scholar]
  45. Fuchs J, Cannon CP. Hirulog in the treatment of unstable angina. Results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) 7 trial. Circulation. 1995;92:727–33. [CrossRef] [PubMed] [Google Scholar]
  46. Antman EM, McCabe CH, Braunwald E. Bivalirudin as a replacement for unfractionated heparin in unstable angina/non-ST-elevation myocardial infarction: observations from the TIMI 8 trial. The Thrombolysis in Myocardial Infarction. American Heart Journal. 2002;143:229–34. [CrossRef] [PubMed] [Google Scholar]
  47. Potzsch B, Madlener K, Seelig C, et al. Monitoring of r-hirudin anticoagulation during cardiopulmonary bypass-assessment of the whole blood ecarin clotting time. Thrombosis & Haemostasis. 1997;77:920–5. [Google Scholar]
  48. Despotis GJ, Hogue CW, Saleem R, et al. The relationship between hirudin and activated clotting time: implications for patients with heparin-induced thrombocytopenia undergoing cardiac surgery. Anesthesia & Analgesia. 2001;93:28–32. [CrossRef] [PubMed] [Google Scholar]
  49. Potzsch B, Hund S, Madlener K, Unkrig C, Muller-Berghaus G. Monitoring of recombinant hirudin: assessment of a plasma-based ecarin clotting time assay. Thrombosis Research. 1997;86:373–83. [CrossRef] [PubMed] [Google Scholar]
  50. Koster A, Despotis G, Gruendel M, et al. The plasma supplemented modified activated clotting time for monitoring of heparinization during cardiopulmonary bypass: a pilot investigation. Anesthesia & Analgesia. 2002;95:26–30. [CrossRef] [PubMed] [Google Scholar]
  51. Koster A, Kuppe H, Crystal GJ, Mertzlufft F. Cardiovascular surgery without cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II using anticoagulation with recombinant hirudin. Anesthesia & Analgesia. 2000;90:292–8. [CrossRef] [PubMed] [Google Scholar]
  52. Cho L, Kottke-Marchant K, Lincoff AM, et al. Correlation of point-of-care ecarin clotting time versus activated clotting time with bivalirudin concentrations. American Journal of Cardiology. 2003;91:1110–3. [CrossRef] [Google Scholar]
  53. Demir M, Iqbal O, Untch B, et al. Ecarin clotting time is sensitive to heparinoids: comparison of two different techniques. Clinical & Applied Thrombosis/Hemostasis. 2001;7:38–43. [CrossRef] [PubMed] [Google Scholar]
  54. Pivalizza EG. Monitoring of hirudin therapy with the Thrombelastograph. Journal of Clinical Anesthesia. 2002;14:456–8. [CrossRef] [PubMed] [Google Scholar]
  55. Bittl JA, Strony J, Brinker JA, et al. Treatment with bivalirudin (Hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina. Hirulog Angioplasty Study Investigators. NEJM. 1995;333:764–9. [CrossRef] [PubMed] [Google Scholar]
  56. Topol EJ, Bonan R, Jewitt D, et al. Use of a direct antithrombin, hirulog, in place of heparin during coronary angioplasty. Circulation. 1993;87:1622–9. [CrossRef] [PubMed] [Google Scholar]
  57. Mariani MA, Gu YJ, Boonstra PW, et al. Procoagulant activity after off-pump coronary operation: is the current anticoagulation adequate? Ann Thorac Surg. 1999;67:1370–5. [CrossRef] [Google Scholar]
  58. The Direct Thrombin Inhibitor Trialists’ Collaborative G. Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients’ data. [comment]. Lancet. 2002;359:294–302. [CrossRef] [PubMed] [Google Scholar]
  59. Kong DF, Topol EJ, Bittl JA, et al. Clinical outcomes of bivalirudin for ischemic heart disease. Circulation. 1999;100:2049–53. [CrossRef] [PubMed] [Google Scholar]
  60. Lincoff AM, Bittl JA, Harrington RA, et al. Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial. JAMA. 2003;289:853–63. [CrossRef] [PubMed] [Google Scholar]
  61. Puskas JD, Thourani VH, Marshall JJ, et al. Clinical outcomes, angiographic patency, and resource utilization in 200 consecutive off-pump coronary bypass patients. Ann Thorac Surg. 2001;71:1477–83; discussion 1483-4. [CrossRef] [Google Scholar]
  62. Angelini GD, Taylor FC, Reeves BC, Ascione R. Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials. Lancet. 2002;359:1194–9. [CrossRef] [PubMed] [Google Scholar]
  63. Zehr KJ, Handa N, Bonilla LF, Abel MD, Holmes DRJr. Pitfalls and results of immediate angiography after off-pump coronary artery bypass grafting. Heart Surg Forum. 2000;3:293–9. [Google Scholar]
  64. Kim KB, Lim C, Lee C, et al. Off-pump coronary artery bypass may decrease the patency of saphenous vein grafts. Ann Thorac Surg. 2001;72:S1033–7. [CrossRef] [Google Scholar]
  65. Spiess BD, DeAnda A, McCarthy A, et al. Off pump CABG in a patient with HITT anticoagulated with bivalirudin: a case report. Anesth Analg. 2002;93:SCA70. [Google Scholar]
  66. Davis Z, Anderson R, Short D, Garber D, Valgiusti A. Favorable outcome with bivalirudin anticoagulation during cardiopulmonary bypass. Ann Thorac Surg. 2003;75:264–5. [CrossRef] [Google Scholar]

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