Open Access
J Extra Corpor Technol
Volume 55, Number 4, December 2023
Page(s) 159 - 166
Published online 15 December 2023
  1. Baldwin CM, Lyseng-Williamson KA, Keam SJ (2008) Meropenem: a review of its use in the treatment of serious bacterial infections. Drugs 68(6), 803–38. [CrossRef] [PubMed] [Google Scholar]
  2. Brodie D, Slutsky AS, Combes A (2019) Extracorporeal life support for adults with respiratory failure and related indications: a review. JAMA 322(6), 557–68. [CrossRef] [PubMed] [Google Scholar]
  3. Schaffer P, Chowdhury R, Jordan K, DeWitt J, Elliott J, Schroeder K (2022) Outcomes of continuous renal replacement therapy in a community health system. J Intensive Care Med 37(8), 1043–8. [CrossRef] [PubMed] [Google Scholar]
  4. Ricci Z, Goldstein SL (2016) Pediatric continuous renal replacement therapy. Contrib Nephrol 187, 121–30. [CrossRef] [PubMed] [Google Scholar]
  5. Watson RS, Crow SS, Hartman ME, Lacroix J, Odetola FO (2017) Epidemiology and outcomes of pediatric multiple organ dysfunction syndrome. Pediatr Crit Care Med 18(3_suppl Suppl 1), S4–16. [CrossRef] [PubMed] [Google Scholar]
  6. Hayes LW, Oster RA, Tofil NM, Tolwani AJ (2009) Outcomes of critically ill children requiring continuous renal replacement therapy. J Crit Care 24(3), 394–400. [CrossRef] [PubMed] [Google Scholar]
  7. Cheng V, Abdul-Aziz MH, Roberts JA, Shekar K (2019) Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients. Expert Opin Drug Metab Toxicol 15(2), 103–12. [CrossRef] [PubMed] [Google Scholar]
  8. Nolin TD, Aronoff GR, Fissell WH, Jain L, Madabushi R, Reynolds K, et al. (2015) Pharmacokinetic assessment in patients receiving continuous RRT: perspectives from the Kidney Health Initiative. Clin J Am Soc Nephrol 10(1), 159–64. [CrossRef] [PubMed] [Google Scholar]
  9. McDaniel CG, Honeycutt CC, Watt KM (2021) Amiodarone extraction by the extracorporeal membrane oxygenation circuit. J Extra Corpor Technol 53(1), 68–74. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  10. Green DJ, Watt KM, Fish DN, McKnite A, Kelley W, Bensimhon AR (2022) Cefepime extraction by extracorporeal life support circuits. J Extra Corpor Technol 54(3), 212–22. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  11. Clewell HJ, Teeguarden J, McDonald T, Sarangapani R, Lawrence G, Covington T, et al. (2002) Review and evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. Crit Rev Toxicol 32(5), 329–89. [CrossRef] [PubMed] [Google Scholar]
  12. Lorenzin A, Garzotto F, Alghisi A, Neri M, Galeano D, Aresu S, et al. (2016) CVVHD treatment with CARPEDIEM: small solute clearance at different blood and dialysate flows with three different surface area filter configurations. Pediatr Nephrol 31(10), 1659–65. [CrossRef] [PubMed] [Google Scholar]
  13. McQueen CA (2003) Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity. Toxicolog Sci 73(2), 279–86. [CrossRef] [Google Scholar]
  14. Nakamura AT, Btaiche IF, Pasko DA, Jain JC, Mueller BA (2004) In vitro clearance of trace elements via continuous renal replacement therapy. J Ren Nutr 14(4), 214–9. [CrossRef] [PubMed] [Google Scholar]
  15. Watt KM, Cohen-Wolkowiez M, Williams DC, Bonadonna DK, Cheifetz IM, Thakker D, et al. (2017) Antifungal extraction by the extracorporeal membrane oxygenation circuit. J Extra Corpor Technol 49(3), 150–9. [PubMed] [Google Scholar]
  16. Wildschut ED, Ahsman MJ, Allegaert K, Mathot RAA, Tibboel D (2010) Determinants of drug absorption in different ECMO circuits. Intensive Care Med 36(12), 2109–16. [CrossRef] [PubMed] [Google Scholar]
  17. Dzierba AL, Abrams D, Brodie D (2017) Medicating patients during extracorporeal membrane oxygenation: the evidence is building. Crit Care 21(1), 66. [CrossRef] [PubMed] [Google Scholar]
  18. Shekar K, Roberts JA, Mcdonald CI, Ghassabian S, Anstey C, Wallis SC, et al. (2015) Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study. Crit Care 14(19), 164. [CrossRef] [PubMed] [Google Scholar]
  19. Sherwin J, Heath T, Watt K (2016) Pharmacokinetics and Dosing of Anti-infective Drugs in Patients on Extracorporeal Membrane Oxygenation: A Review of the Current Literature. Clin Ther 38(9), 1976–94. [CrossRef] [PubMed] [Google Scholar]
  20. Zamoner W, de Freitas FM, Garms DSS, de Oliveira MG, Balbi AL, Ponce D (2016). Pharmacokinetics and pharmacodynamics of antibiotics in critically ill acute kidney injury patients. Pharmacolo Res Perspect 4(6), e00280. [Google Scholar]
  21. Pea F, Viale P, Pavan F, Furlanut M (2007) Pharmacokinetic considerations for antimicrobial therapy in patients receiving renal replacement therapy. Clin Pharmacokinet 46(12), 997–1038. [CrossRef] [PubMed] [Google Scholar]
  22. Ulldemolins M, Vaquer S, Llauradó-Serra M, Pontes C, Calvo G, Soy D, et al. (2014) Beta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy. Crit Care 18(3), 227. [CrossRef] [PubMed] [Google Scholar]
  23. Cies JJ, Nikolos P, Moore WS, Giliam N, Low T, Marino D, et al. (2022) Oxygenator impact on meropenem/vaborbactam in extracorporeal membrane oxygenation circuits. Perfusion, 37(7), 729–37. [CrossRef] [PubMed] [Google Scholar]
  24. Bakdach D, Elajez R, Bakdach AR, Awaisu A, De Pascale G, Ait Hssain A (2022) Pharmacokinetics, pharmacodynamics, and dosing considerations of novel β-lactams and β-lactam/β-lactamase inhibitors in critically ill adult patients: focus on obesity, augmented renal clearance, renal replacement therapies, and extracorporeal membrane oxygenation. J Clin Med 11(23), 6898. [CrossRef] [PubMed] [Google Scholar]
  25. Gijsen M, Dreesen E, Annaert P, Nicolai J, Debaveye Y, Wauters J, et al. (2021) Meropenem pharmacokinetics and target attainment in critically ill patients are not affected by extracorporeal membrane oxygenation: a matched cohort analysis. Microorganisms 9(6), 1310. [CrossRef] [PubMed] [Google Scholar]
  26. Shekar K, Roberts JA, Ghassabian S, Mullany DV, Wallis SC, Smith MT, et al. (2013) Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern? J Antimicrob Chemother 68(3), 726–7. [CrossRef] [PubMed] [Google Scholar]
  27. Shekar K, Fraser JF, Taccone FS, Welch S, Wallis SC, Mullany DV, et al. (2014) The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study. Crit Care 18(6), 565. [CrossRef] [PubMed] [Google Scholar]
  28. Donadello K, Antonucci E, Cristallini S, Roberts JA, Beumier M, Scolletta S, et al. (2015) β-Lactam pharmacokinetics during extracorporeal membrane oxygenation therapy: A case–control study. Int J Antimicrob Agents 45(3), 278–82. [CrossRef] [PubMed] [Google Scholar]
  29. Shekar K, Roberts JA, Mcdonald CI, Fisquet S, Barnett AG, Mullany DV, et al. (2012) Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Crit Care 16(5), R194. [CrossRef] [PubMed] [Google Scholar]
  30. Bilgrami I, Roberts JA, Wallis SC, Thomas J, Davis J, Fowler S, et al. (2010) Meropenem dosing in critically ill patients with sepsis receiving high-volume continuous venovenous hemofiltration. Antimicrob Agents Chemother 54(7), 2974–8. [CrossRef] [PubMed] [Google Scholar]
  31. Ulldemolins M, Soy D, Llaurado-Serra M, Vaquer S, Castro P, Rodríguez AH, et al. (2015) Meropenem population pharmacokinetics in critically ill patients with septic shock and continuous renal replacement therapy: influence of residual diuresis on dose requirements. Antimicrob Agents Chemother 59(9), 5520–8. [CrossRef] [PubMed] [Google Scholar]
  32. Li L, Li X, Xia Y, Chu Y, Zhong H, Li J, et al. (2020) Recommendation of antimicrobial dosing optimization during continuous renal replacement therapy. Front Pharmacol 11, 786. [CrossRef] [PubMed] [Google Scholar]
  33. Smith PB, Cohen-Wolkowiez M, Castro LM, Poindexter B, Bidegain M, Weitkamp JH, et al. (2011) Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections. Pediatr Infect Dis J 30(10), 844–9. [CrossRef] [PubMed] [Google Scholar]
  34. Scharf C, Paal M, Schroeder I, Vogeser M, Draenert R, Irlbeck M, et al. (2020) Therapeutic drug monitoring of meropenem and piperacillin in critical illness – experience and recommendations from one year in routine clinical practice. Antibiotics (Basel) 9(3), 131. [CrossRef] [PubMed] [Google Scholar]
  35. Bulik CC, Fauntleroy KA, Jenkins SG, Abuali M, LaBombardi VJ, Nicolau DP, et al. (2010) Comparison of meropenem mics and susceptibilities for carbapenemase-producing Klebsiella pneumoniae isolates by various testing methods. J Clin Microbiol 48(7), 2402–6. [CrossRef] [PubMed] [Google Scholar]
  36. Saito J, Shoji K, Oho Y, Aoki S, Matsumoto S, Yoshida M, et al. (2020) Meropenem pharmacokinetics during extracorporeal membrane oxygenation and continuous haemodialysis: a case report. J Glob Antimicrob Resist 1(22), 651–5. [CrossRef] [PubMed] [Google Scholar]
  37. Jang SM, Infante S, Abdi Pour A (2020) Drug dosing considerations in critically ill patients receiving continuous renal replacement therapy. Pharmacy (Basel) 8(1), 18. [CrossRef] [PubMed] [Google Scholar]
  38. Mouton JW, van den Anker JN (1995) Meropenem clinical pharmacokinetics. Clin Pharmacokinet 28(4), 275–86. [CrossRef] [PubMed] [Google Scholar]
  39. Moon YSK, Chung KC, Gill MA (1997) Pharmacokinetics of meropenem in animals, healthy volunteers, and patients. Clin Infect Dis 1, 24(Supplement_2), S249–55. [CrossRef] [PubMed] [Google Scholar]
  40. Preston TJ, Ratliff TM, Gomez D, Olshove VF, Nicol KK, Sargel CL, et al. (2010) Modified surface coatings and their effect on drug adsorption within the extracorporeal life support circuit. J Extra Corpor Technol 42(3), 199–202. [PubMed] [Google Scholar]
  41. Williams DC, Turi JL, Hornik CP, Bonnadonna DK, Williford WL, Walczak RJ, et al. (2015) Circuit oxygenator contributes to extracorporeal membrane oxygenation-lnduced hemolysis. ASAIO J 61(2), 190–5. [CrossRef] [PubMed] [Google Scholar]
  42. Imburgia CE, Rower JE, Green DJ, Mcknite AM, Kelley WE, Reilly CA, et al. (2022) Remdesivir and GS-441524 extraction by ex vivo extracorporeal life support circuits. ASAIO J 68(9), 1204. [CrossRef] [PubMed] [Google Scholar]
  43. Póvoa P, Moniz P, Pereira JG, Coelho L (2021) Optimizing antimicrobial drug dosing in critically ill patients. Microorganisms 9(7), 1401. [CrossRef] [PubMed] [Google Scholar]
  44. Kang S, Yang S, Hahn J, Jang JY, Min KL, Wi J, et al. (2022) Dose optimization of meropenem in patients on veno-arterial extracorporeal membrane oxygenation in critically ill cardiac patients: pharmacokinetic/pharmacodynamic modeling. J Clin Med, 11(22), 6621. [CrossRef] [PubMed] [Google Scholar]
  45. Watt KM, Cohen-Wolkowiez M, Barrett JS, Sevestre M, Zhao P, Brouwer KLR, et al. (2018) Physiologically based pharmacokinetic approach to determine dosing on extracorporeal life support: fluconazole in children on ECMO. CPT: pharmacometrics & systems. Pharmacology 7(10), 629–37. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.