Issue |
J Extra Corpor Technol
Volume 22, Number 3, September 1990
|
|
---|---|---|
Page(s) | 137 - 139 | |
DOI | https://doi.org/10.1051/ject/1990223137 | |
Published online | 21 August 2023 |
Lecture
Alpha-Stat versus pH-Stat: Implications for the Brain During Cardiopulmonary Bypass
Department of Anaesthesia, University Hospital, University of Western Ontario, London, Ontario, Canada
* Address correspondence to: Dr. John M. Murkin, Dept. of Anesthesia, University Hospital. 339 Windermere Road, London, Ontario N6A 5A5 Canada.
During cardiac surgery, systemic hypothermia is often utilized to augment cardioplegic myocardial preservation. The ensuing reduction in metabolic activity is directly related to the decrease in temperature as predicted by Vant Hoff's law. Lowered metabolic-activity decreases oxygen utilization, thus increasing tissue tolerance for reductions in oxygen delivery.
Among numerous other physiologic effects, hypothermia increases the solubility of O2 and CO2 in blood, producing a fall in gaseous partial pressures, while total gas content remains unchanged. When this occurs with CO2, the corresponding rise in pH may be perceived as a "respiratory alkalosis."
Key words: Cardiopulmonary bypass / hypothermia / pH management
© 1990 AMSECT
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