Protamine dose to neutralize heparin at the completion of cardiopulmonary bypass can be reduced significantly without affecting post-operative bleeding

Open Access

Table 1a

Patient information, Protamine doses, ppACT/bACT distribution.

	1.0 Ratio^a (Avg ± SD)	P-value (1.0 vs 0.9)	0.9 Ratio^a (Avg ± SD)	p-value (0.9 vs 0.8)	0.8 Ratio^a (Avg ± SD)	P-value (1.0 vs 0.8)
Height (cm)	171.6 ± 10.2	0.15	173.1 ± 11.2	0.11	171.5 ± 9.9	0.90
Weight (kg)	84.6 ± 17.1	0.04	88.4 ± 21.1	0.01	83.7 ± 17.9	0.59
BMI	28.6 ± 4.9	0.18	29.4 ± 6.1	0.07	28.4 ± 5.2	0.57
BSA (m²)	1.97 ± 0.23	0.05	2.02 ± 0.27	0.02	1.96 ± 0.23	0.62
Platelets (counts/nL blood)	225 ± 65	0.59	228 ± 63	0.63	225 ± 68	0.97
CPB time (min)	135 ± 60	0.03	148 ± 61	0.23	141 ± 65	0.35
Cross-Clamp Time (min)	97 ± 48	0.04	106 ± 43	0.43	102 ± 47	0.22
First Heparin Bolus (FHB, IU)	25959 ± 7003	0.16	26938 ± 7249	0.06	25693 ± 6129	0.68
Total Heparin Dose (THD, IU)	38007 ± 10823	0.33	39033 ± 10691	0.18	38427 ± 9853	0.68
First Hep. Conc.^b	3.5 ± 0.9	0.42	3.5 ± 0.7	0.94	3.5 ± 0.6	0.37
Last Hep. Conc.^c	2.7 ± 0.7	0.01	2.5 ± 0.6	0.13	2.6 ± 0.6	0.25
Cal. Patient Protamine dose (CPP, mg)	152 ± 53	0.00	133 ± 46	0.00	116 ± 37	0.00
Cal. Pump Protamine dose (mg)	35 ± 9	0.00	29 ± 7	0.00	27 ± 6	0.00
Cal. Total Protamine dose (CTP, mg)	187 ± 60	0.00	163 ± 51	0.00	143 ± 41	0.00
Actual Protamine Dose (APD, mg)	174 ± 53	0.00	136 ± 46	0.00	121 ± 36	0.00
Baseline ACT (bACT, sec)	132 ± 16	0.94	131 ± 20	0.55	132 ± 14	0.54
Post-Protamine ACT (ppACT)	112 ± 15	0.00	119 ± 18	0.36	118 ± 14	0.00
ppACT/bACT (%)	86 ± 12	0.00	92 ± 18	0.07	90 ± 13	0.00

1.0 Ratio 209 patients, 0.9 Ratio 211 patients, 0.8 Ratio 212 patients.

HC measured by HPT prior to CPB after FHB.

HC measured by HPT 5-10 minutes after cross-clamp comes off.

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