Table 1
Patient demographics and clinical characteristics of entire VA-ECLS cohort stratified by mean PaO2 levels in the first 48 h into non-hyperoxia group (PaO2 ≤ 233 mmHg) hyperoxia group (PaO2 > 233 mmHg).
| Variables | Total Cohort | Non-hyperoxia group | Hyperoxia group | p-value |
|---|---|---|---|---|
| (n = 229) | (PaO2 ≤ 233 mmHg) (n = 161) | (PaO2 233 mmHg) (n = 68) | ||
| Age (months) | 2.5 (0.3, 19.0) | 1.5 (0.2, 17.2) | 4.6 (0.4, 27.8) | 0.019 |
| Age Group | 0.345 | |||
| Neonatal | 168 (73.4%) | 121 (75.2%) | 47 (69.1%) | |
| Pediatrics | 61 (26.6%) | 40 (24.8%) | 21 (30.9%) | |
| Weight (kg) | 4.4 (3.2, 10.7) | 3.9 (3.1, 9.5) | 5.5 (3.3, 11.9) | 0.178 |
| Height (cm) | 54.0 (49.0, 80.0) | 53.0 (49.0, 75.5) | 61.8 (50.0, 84.3) | 0.115 |
| BSA (m2) | 0.3 (0.2, 0.5) | 0.2 (0.2, 0.4) | 0.3 (0.2, 0.5) | 0.155 |
| Race | 0.204 | |||
| Black | 104 (45.4%) | 75 (46.6%) | 29 (42.6%) | |
| White | 87 (38.0%) | 55 (34.2%) | 32 (47.1%) | |
| Hispanic | 26 (11.4%) | 21 (13.0%) | 5 (7.4%) | |
| Other | 12 (5.2%) | 10 (6.2%) | 2 (2.9%) | |
| Sex | 0.410 | |||
| Female | 115 (50.2%) | 78 (48.4%) | 37 (54.4%) | |
| Male | 114 (49.8%) | 83 (51.6%) | 31 (45.6%) | |
| ECLS indication | 0.0004 | |||
| Cardiac | 112 (48.9%) | 71 (44.1%) | 41 (60.3%) | |
| ECPR | 65 (28.4%) | 42 (26.1%) | 23 (33.8%) | |
| Pulmonary | 52 (22.7%) | 48 (29.8%) | 4 (5.9%) | |
| Time from admission to ECLS Initiation | 78.5 (14.0, 356.0) | 72.5 (14.0, 411.0) | 100.0 (7.0, 306.0) | 0.997 |
| Initial ECLS flow (mL/kg/min) | 114 (94, 116) | 109 (100, 1212) | 128 (97, 131) | 0.018 |
| Duration of ECLS run (hours) | 111.5 (65.5, 184.5) | 111.5 (65.5, 195.5) | 110.5 (66.5, 161.5) | 0.412 |
| ECLS Complications: | ||||
| Cardiovascular | 87 (45.8%) | 51 (39.8%) | 36 (58.1%) | 0.018 |
| Hemorrhagic | 86 (45.3%) | 58 (45.3%) | 28 (45.2%) | 0.984 |
| Mechanical | 75 (39.5%) | 58 (45.3%) | 17 (27.4%) | 0.018 |
| Renal | 103 (54.2%) | 68 (53.1%) | 35 (56.5%) | 0.666 |
| Neurologic | 46 (24.2%) | 28 (21.9%) | 18 (29.0%) | 0.280 |
| Metabolic | 29 (15.3%) | 18 (14.1%) | 11 (17.7%) | 0.509 |
| Infection | 9 (4.7%) | 7 (5.5%) | 2 (3.2%) | 0.495 |
| Reason for coming off | 0.049 | |||
| Died or Poor Prognosis | 48 (21.1%) | 26 (16.4%) | 22 (32.4%) | |
| ECLS Complication | 16 (7.0%) | 11 (6.9%) | 5 (7.4%) | |
| Expected Recovery | 153 (67.4%) | 116 (73.0%) | 37 (54.4%) | |
| Unknown | 1 (0.4%) | 1 (0.6%) | 0 (0.0%) | |
| VAD | 9 (4.0%) | 5 (3.1%) | 4 (5.9%) | |
| Missing | 2 | 2 | 0 | |
| AKI Stage II or III | 160 (75.8%) | 111 (74.5%) | 49 (79.0%) | 0.483 |
| Mortality | 102 (44.5%) | 65 (40.4%) | 37 (54.4%) | 0.050 |
Results Depicted in n (%), and Median (Interquartile Range/IQR). ECLS: Extracorporeal Life Support; VA: Veno-Arterial; VAD: Ventricular Assist Device; AKI: Acute Kidney Injury.
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