Open Access
Review
Table 1
Article overviews with notable characteristics of each. Definitions of hyperoxia are mentioned to highlight the variety. RI: reoxygenation injury; ROS: reactive oxygen species; IR: inflammatory response; LOS: length of stay.
| Source | Sample size | Age range | CPB duration mean (min) | Definition of Hyperoxia | Cyanotic? | Outcome |
|---|---|---|---|---|---|---|
| Allen et al. [4], US | 21 | Infants | Not mentioned | PaO2 of 400–550 mmHg | Cyanotic | RI, ROS |
| Beshish et al. [3], US | 469 | <1 year | 128 min cyanotic/98 acyanotic | PaO2 of >313 mmHg | Not mentioned | Mortality, including LOS |
| Bulutcu et al. [5], Turkey | 24 | Infants | 116 | PaO2 of 300–350 mmHg | 14 cyanotic/10 acyanotic | RI ROS |
| Caputo et al. [6], UK | 64 | 6 months–4 years | 86 | PaO2 of 150–180 mmHg in cyanotic patient | Cyanotic | RI, cerebral injury, hepatic injury |
| Caputo et al. [7], UK | 169 | 4 months–4 years | 96 | PaO2 of 150–200 mmHg in cyanotic patient | Cyanotic | Inc transfusion and kidney injury |
| Cashen et al. [8], US | 484 | <19 years | Not mentioned | PaO2 of >200 mmHg on ECMO | n/a | Mortality, kidney failure, inc LOC |
| Gretchen et al. [9], US | 100 | >1 month–18 years | 73 | PaO2 of 150–180 mmHg | Mostly acyanotic | Hemolysis, ROS |
| Kagawa et al. [10], Japan | 22 | 2–21 years | 122 | PaO2 of 200–300 mmHg | Acyanotic | IR, inc lung injury, ROS |
| Modi et al. [11], UK | 29 | 4.5 months–14.5 years | Not mentioned | No definition | 20 cyanotic/9 acyanotic | RI |
| Sznycer-Taub et al. [12], US | 93 | 5–20 days | 156 | PaO2 of >193 mmHg on ECMO | n/a | Mortality, kidney injury, inc LOC |
| Varrica et al. [13], Italy | 48 | Infants | 81 | No definition | Cyanotic | RI, cerebral injury |
| Yang et al. [14], China | 376 | 6 months–6 years | 123 | PaO2 of >250 mmHg | Cyanotic | RI |
| Zhu et al. [15] | 20 | Pediatric | Not mentioned | CPB initiation with FiO2 | Cyanotic | RI, cerebral injury |
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