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Table 2
Patient demographics and clinical characteristics stratified by hyperoxia severity.
| Variables | Normoxia PaO2 ≤ 100 mmHg (n = 48) | Mild hyperoxia PaO2 101–200 mmHg (n = 94) | Moderate hyperoxia PaO2 201–300 mmHg (n = 62) | Severe hyperoxia PaO2 > 300 mmHg (n = 25) | p-value |
|---|---|---|---|---|---|
| Age (months) | 0.5 (0.1, 2.9) | 2.5 (0.3, 18.3) | 7.9 (0.5, 50.7) | 3.2 (0.4, 9.6) | 0.001 |
| Age group | 0.01 | ||||
| Neonates | 42 (87.5%) | 69 (73.4%) | 37 (59.7%) | 20 (80.0%) | |
| Pediatrics | 6 (12.5%) | 25 (26.6%) | 25 (40.3%) | 5 (20.0%) | |
| Weight (kg) | 3.4 (2.9, 4.4) | 4.3 (3.2, 11.4) | 7.4 (3.5, 19.2) | 4.4 (3.0, 8.1) | 0.001 |
| BSA (m2) | 0.2 (0.2, 0.3) | 0.2 (0.2, 0.5) | 0.3 (0.2, 0.7) | 0.3 (0.2, 0.4) | 0.007 |
| Race | 0.2 | ||||
| Black | 29 (60.4%) | 37 (39.4%) | 104 (45.4%) | 104 (45.4%) | |
| White | 3 (6.3%) | 15 (16.0%) | 87 (38.0%) | 87 (38.0%) | |
| Hispanic | 3 (6.3%) | 6 (6.4%) | 26 (11.4%) | 26 (11.4%) | |
| Other | 13 (27.1%) | 36 (38.3%) | 12 (5.2%) | 12 (5.2%) | |
| Sex | 0.7 | ||||
| Female | 21 (43.8%) | 47 (50.0%) | 33 (53.2%) | 14 (56.0%) | |
| Male | 27 (56.3%) | 47 (50.0%) | 29 (46.8%) | 11 (44.0%) | |
| ECLS Indication | <0.001 | ||||
| Cardiac | 16 (33.3%) | 44 (46.8%) | 37 (59.7%) | 15 (60.0%) | |
| ECPR | 9 (18.8%) | 28 (29.8%) | 20 (32.3%) | 8 (32.0%) | |
| Pulmonary | 23 (47.9%) | 22 (23.4%) | 5 (8.1%) | 2 (8.0%) | |
| Time from admission to ECLS Initiation | 105.0 (25.0, 593.0) | 49.0 (14.0, 353.0) | 78.5 (5.5, 257.0) | 111.5 (24.0, 313.0) | 0.57 |
| Duration of ECLS (hours) | 118.0 (43.5, 248.0) | 112.0 (65.0, 185.0) | 101.0 (68.0, 158.0) | 125.0 (72.0, 186.0) | 0.68 |
| ECLS Complications: | |||||
| Cardiovascular | 18 (45.0%) | 28 (37.8%) | 26 (51.0%) | 15 (60.0%) | 0.21 |
| Hemorrhagic | 16 (40.0%) | 33 (44.6%) | 25 (49.0%) | 12 (48.0%) | 0.84 |
| Mechanical | 20 (50.0%) | 32 (43.2%) | 13 (25.5%) | 10 (40.0%) | 0.09 |
| Renal | 21 (52.5%) | 39 (52.7%) | 26 (51.0%) | 17 (68.0%) | 0.52 |
| Neurologic | 5 (12.5%) | 21 (28.4%) | 11 (21.6%) | 9 (36.0%) | 0.12 |
| Metabolic | 5 (12.5%) | 11 (14.9%) | 8 (15.7%) | 5 (20.0%) | 0.88 |
| Infection | 4 (10.0%) | 3 (4.1%) | 1 (2.0%) | 1 (4.0%) | 0.33 |
| AKI Stage II or III | 34 (75.6%) | 63 (74.1%) | 43 (71.7%) | 20 (95.2%) | 0.17 |
| Mortality | 19 (39.6%) | 41 (43.6%) | 27 (43.5%) | 16 (64.0%) | 0.23 |
Results depicted as n (%), median (Interquartile range). AKI: Acute Kidney Injury, BSA: Body Surface Area, ECLS: Extracorporeal Life Support; VA: Veno-Arterial.
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