Issue |
J Extra Corpor Technol
Volume 15, Number 4, August 1983
|
|
---|---|---|
Page(s) | 101 - 103 | |
DOI | https://doi.org/10.1051/ject/1983154101 | |
Published online | 15 September 2023 |
Original Article
Extraction of Nitroglycerin by a Membrane Oxygenator
The Ohio State University Hospitals, College of Pharmacy, College of Medicine, and School of Allied Med1cal Professions, Columbus, Ohio
* Direct communications to: Joseph F. Dasta, M.Sc., The Ohio State University, College of Pharmacy, 500 West 12th Avenue, Columbus, OH 43210.
Received:
7
March
1983
Revised:
25
May
1983
Accepted:
16
June
1983
This study examined the extraction efficiency of a membrane oxygenator for nitroglycerin (NTG). An In-Vitro cardiopulmonary bypass circuit was constructed to mimic clinical conditions. A NTG solution (150 ng/ml) was placed into the circuit via a glass cardiotomy reservoir and circulated at 5 L/min for 60 min. Analysis of NTG samples obtained during the study showed that the oxygenator initially extracted 70% of drug entering the device. A small increase in drug concentration was observed for the first 10 min, followed by a continual decrease. By 60 min only 20% of the original drug concentration remained. We conclude that the membrane oxygenator used during cardiopulmonary bypass is capable of substantially extracting NTG.
© 1983 AMSECT
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.