Issue |
J Extra Corpor Technol
Volume 29, Number 4, December 1997
|
|
---|---|---|
Page(s) | 189 - 193 | |
DOI | https://doi.org/10.1051/ject/1997294189 | |
Published online | 18 August 2023 |
Original Article
laboratory Evaluation of a New Membrane Oxygenator with a Built-In Hemoconcentrator
1
Department of Cardiovascular Surgery and Cardiopulmonary Bypass, The Heart Institute of Japan, Tokyo
2
Women's Medical College, and Senko Medical Instruments Manufacturing, Tokyo, Japan
* Address correspondence to: Hiroshi Nishida, MD, Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women's Medical College, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162, Japan
In order to facilitate the handling of cardiopulmonary bypass (CPB) and simplify the circuit, we have developed a new membrane oxyganator with a hemofiltration function. The hollow fiber units for gas exchange and hemofiltration were combined in concentric circles in a cylindrical housing. The total priming volume was 190 ml. Because we used a silicon-coated hollow fiber membrane for gas exchange, this oxygenator was completely resistant to serum leakage. The gas exchange and hemofiltration sections both have a blood-outside flow configuration. All blood flows in a radial direction from around the central core to the surrounding hollow fiber units, first to the hemofiltration portion and then to the gas exchange section. Filtered fluid was easily collected through a stopcock mechanism. The oxygen transfer rate was 312 ml/min at a blood flow rate of 6 L/min, and the ultrafiltration rate was 3.5 L/hour at a blood flow rate of 4 L/min with 25% hematocrit and 200 mmHg transmembrane pressure in an in vitro study. The pressure drop was 62 mmHg at a blood flow rate of 4 L/min. We found no adverse effects in an in vivo study using a mongrel dog. In conclusion, this durable combined device could achieve excellent and simplified hemoconcentration by having all the blood in the unit flow through the hemofiltration portion, and may be useful not only in CPB during open heart surgery, but also in extracorporeal membrane oxygenation.
Key words: membrane oxygenator / hemofiltration / hollow fiber
© 1997 AMSECT
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